Professor Stephen Clarke, OAM is a medical oncologist and translational cancer researcher based at the University of Sydney. Prof Clarke obtained his medical degree (MB BS) through the University of Sydney in 1983, he went on to complete a FRACP in Medical Oncology in 1990 at the Royal North Shore Hospital in Sydney. From 1991 – 1994 he worked in the Drug Development Unit of the Institute of Cancer Research/ Royal Marsden Cancer Hospital in Sutton, Surrey, UK. Later on, in 2012, Prof Clarke obtained a PhD in cancer pharmacology from the University of London and an MD from the University of Sydney.

On returning to Australia, he worked at a number of cancer centres before eventually returning to the Royal North Shore in 2010. Professor Clarke is a world renowned cancer pharmacologist and has been an invited speaker at numerous national and international meetings and has over 200 publications in peer-reviewed journals.

Furthermore, in 2013 he was awarded the Eric Susman Prize of the Royal Australasian College of Physicians, which is awarded annually to a Fellow of the College for the most outstanding contribution to the knowledge of any branch of internal medicine. The prize is one of the College’s most prestigious and important awards, with the inaugural award made in 1962.

Research Interests

Prof Clarkes’ clinical research focuses on colorectal cancer (CRC), in particular the relationship between inflammation, impaired outcomes in CRC and malignant mesothelioma.

He has been involved in the assessment of predictors of outcome in patients with colorectal cancer and studies of cancer drug metabolism. Additionally, his laboratory made major findings in relation the impact of cancer associated inflammation on chemotherapy toxicity and survival.

Grants/ Funding

NHMRC

“The Effects of Ageing on Cancer Chemotherapy”

Project Grant 2000

“Cross-sectional study of nutrition, psychosocial support & cytokines in advanced cancer patients

Palliative Care SRDC grant 2003

“Impact of tumours on levels of human drug metabolizing enzymes”

Project Grant 2004

“Cognitive function and fatigue in cancer patients after chemotherapy”

Project Grant 2006

“Nutrition and rehabilitation in advanced cancer patients”

Palliative Care Priority Driven Research Grant 2006

“Inter-ethnic differences in tolerance of anti-cancer drugs”

Project Grant 2007

“Improving the use of chemotherapy by targeting the inflammatory response

Project Grant 2009

“Determining the tumour suppressor function of the MCC gene and its significance to treatment outcomes in colorectal cancer”

Project Grant 2011

“Advance care planning in incurable cancer patients with disease progression on first line chemotherapy: a randomised trial.”

Project Grant 2012

“Therapeutic targeting of cell cycle checkpoint aberrations in pancreatic cancer: personalized medicine in action”

Project Grant 2014

 

Cancer Institute NSW

“ProteomeX MS and personnel support for the new facility”

Research Infrastructure Grant 2005

“Digital Imaging Quantification Station”

Research Infrastructure Grant 2005

“Equipment and personnel support for Establishment of a centre for the Preclinical, Clinical, Pharmacokinetics and Pharmacogenetic Evaluation of Cancer Drugs, Nutritional Interventions and Complementary Therapies”

Research Infrastructure Grant 2005

“Image Analyser for Tissue Pathology Research”

Research Equipment Grant 2006

“Cell sorting Facility to Support Patient-Orientated Cancer Research Projects”

Research Infrastructure Grant 2007

“NSW Cancer Proteomics Infrastructure Initiative (NCPII)”

Research Infrastructure Grant 2007

“Use of proteomic analyses to improve the management of colorectal cancer (CRC) – the SCRIPT for CRC Project”

Translational Program Grant 2007

“A mass spectrometer for cancer biomarker research”

Research Equipment Grant 2010

“GenomeLab GeXP Genetic Analysis System for the Multi-Disciplinary Sydney Cancer Gene Expression Facility”

Research Equipment Grant 2010

“Identifying New Plasma Markers In Mesothelioma”

Research Innovation Grant 2010

“Northern Translational Cancer Research Unit”

Translational Cancer Research Unit Establishment Grant 2011

“The creation of a readily accessible and clinically annotated tissue bank of paraffin blocks containing tumour to mirror and expand frozen tissue already collected by the Kolling Tumour Banks.”

Research Infrastructure Grant 2012

“MALDI MS Imaging for Cancer Biomarker Discovery in the Northern Translational Cancer Research Unit”

Research Infrastructure Grant 2012

REG/ Nanostring nCounter

Research Equipment Grant 2014

“Northern Translational Cancer Research Centre”

Translational Cancer Research Centre Establishment Grant 2014

NSW Cancer Council

1998       NSW Cancer Council Project Grant – Rivory L.P., Clarke S.J., Bishop J., Seale J.P. “Overcoming inter-individual variability in cancer chemotherapy”. 2000-2002: $186,342 ($62,114 p.a.)

“Building capacity in pharmacogenomics across NSW: PRIMe (Pharmacogenomic Research for Individualised Medicine)”

Research Program Grant in Cancer Pharmacogenomics 2009

“Genotype Guided Cancer Therapy (Genomic Theranostics)”

Strategic Research Partnership Grant 2011

 

National Institute of Complementary Medicine

“Clinical studies of the efficacy & tolerability of systemically administered Complementary & Alternative Medicine (CAM) in conjunction with standard therapy in cancer patients.”

Research Program Developmental Grant 2009

“Randomized clinical trial: Impact of Medical Qigong on wellbeing of women with breast cancer after adjuvant chemotherapy”

Integrated Care Research Program Scale-Up Grant 2009

 

The University of Sydney

“Developing the Erythromycin Breath-test for Use in Medical Oncology”

Research Grant 1999

”Ranitidine: A potential tool to measure P-glycoprotein activity”

College of Health Sciences Grant 2000

“Predictors of Cancer Drug Metabolism”

Bridging Support Grant 2008

“Bruker Daltonics autoflex speed MALDI-TOF/TOF mass spectrometer, with associated Biomarker Identification and MALDI-Imaging solutions”

Cancer Research Fund Research Infrastructure Grants 2011

“Bruker Daltonics autoflex speed MALDI-TOF/TOF mass spectrometer, with associated Biomarker Identification and MALDI-Imaging solutions”

NHMRC Equipment Grants Scheme 2012

DVC Research/SPARC Implementation – Cancer

The Sydney 1000 Cancer Project 2015

 

Cancer Australia

“Ginkgo biloba preserves cognitive function in women treated with adjuvant chemotherapy for early breast cancer: a double-blind, placebo-controlled, randomised phase III trial”

Priority-driven Collaborative Cancer Research Scheme 2011

From mice to men: biomarker-driven classification of pancreatic cancer to define the gemcitabine/nab-paclitaxel responsive molecular subtype

2015

 

Pfizer

“Characterisation of cognitive impairment in colorectal cancer patients and underlying mechanisms”

Neuroscience Research Grant 2007

 

Lance Armstrong Foundation

“The impact of physical activity on quality of life in thoracic cancer patients”

Lance Armstrong Foundation Young Investigator Award 2008

 

Others

“-80ºC Scientific freezer for storage of blood samples”

Sydney Cancer Centre Foundation Capital 2009

“China:NSW Cancer Genesis, Spread, & Treatment Proteomic Discovery Program”

NSW Office for Science & Medical Research China-NSW Collaborative Research Program 2009

Year Award/ Honour Institution
1990 Medical Board Travelling Fellowship Royal North Shore Hospital
2008 “Eminent Scientist of the Year 2008” in Cancer Research and Clinical Oncology The World Scientists Forum and International Research Promotion Council
2011 Medal of the Order of Australia (OAM) in the General Division. For service to medicine in the disciplines of oncology and pharmacology The Order of Australia
2013 Eric Susman Prize for 2012. Awarded annually to a Fellow of the College. The Prize was awarded for work published over the last two years in cancer-associated inflammation, especially its relationship to impaired outcomes in colorectal cancer (CRC) and malignant mesothelioma. Royal Australasian College of Physicians
2014 Premiers Awards for Outstanding Cancer Research Excellence in Translational Cancer Research
2014 Multidisciplinary Team from ADRI, EnGeneIC Ltd, RPAH, Strathfield Private Hospital, RPAH, CRGH. Strathfield Private Hospital 

Itchins, M., Clarke, S., Pavlakis, N. (2018). Do EGFR tyrosine kinase inhibitors (TKIs) still have a role in EGFR wild-type pre-treated advanced non-small cell lung cancer (NSCLC)?-the shifting paradigm of therapeutics. Translational Lung Cancer Research, 7(Suppl 1), S39-S45. [More Information]

Yu, S., Arima, H., Bertmar, C., Clarke, S., Herkes, G., Krause, M. (2018). Neutrophil to lymphocyte ratio and early clinical outcomes in patients with acute ischemic stroke. Journal of the Neurological Sciences, 387, 115-118. [More Information]

Vardy, J., Dhillon, H., Pond, G., Renton, C., Clarke, S., Tannock, I. (2018). Prognostic indices of inflammatory markers, cognitive function and fatigue for survival in patients with localised colorectal cancer. ESMO Open, 3, e000302. [More Information]

Johnson, S., Butow, P., Bell, M., Detering, K., Clayton, J., Silvester, W., Kiely, B., Clarke, S., Vaccaro, L., Stockler, M., Beale, P., Fitzgerald, N., Tattersall, M. (2017). A Randomized Controlled Trial of an Advance Care Planning Intervention for Patients with Incurable Cancer. The 44th Clinical Oncological Society of Australia Annual Scientific Meeting, .

John, T., Bowden, J., Clarke, S., Fox, S., Garrett, K., Horwood, K., Karapetis, C. (2017). Australian recommendations for EGFR T790M testing in advanced non-small cell lung cancer. Asia-Pacific Journal of Clinical Oncology, 13(4), 296-303. [More Information]

Shinko, D., Diakos, C., Clarke, S., Charles (nee Slaviero), K. (2017). Cancer-Related Systemic Inflammation: The Challenges and Therapeutic Opportunities for Personalized Medicine. Clinical Pharmacology & Therapeutics, 102(4), 599-610. [More Information]

Willowson, K., Bernard, E., Maher, R., Clarke, S., Bailey, D. (2017). Changing Therapeutic Paradigms: Predicting mCRC Lesion Response to Selective Internal Radionuclide Therapy (SIRT) based on Critical Absorbed Dose Thresholds: A Case Study. Asia Oceania Journal of Nuclear Medicine & Biology, 5(1), 66-69. [More Information]

Willowson, K., Hayes, A., Chan, D., Tapner, M., Bernard, E., Maher, R., Pavlakis, N., Clarke, S., Bailey, D. (2017). Clinical and imaging-based prognostic factors in radioembolisation of liver metastases from colorectal cancer: a retrospective exploratory analysis. EJNMMI Research, 7(1), 1-13. [More Information]

Chan, D., Pavlakis, N., Schembri, G., Bernard, E., Hsiao, E., Hayes, A., Barnes, T., Diakos, C., Khasraw, M., Samra, J., Eslick, E., Roach, P., Engel, A., Clarke, S., Bailey, D. (2017). Dual Somatostatin Receptor/FDG PET/CT Imaging in Metastatic Neuroendocrine Tumours: proposal for a Novel Grading Scheme with Prognostic Significance. Theranostics, 7(5), 1149-1158. [More Information]

Oh, B., Eade, T., Kneebone, A., Pavlakis, N., Clarke, S., Eslick, G., River, J., Back, M. (2017). Factors affecting whether or not cancer patients consider using acupuncture. Acupuncture in Medicine, 35(2), 107-113. [More Information]

Dhillon, H., Bell, M., van der Ploeg, H., Turner, J., Kabourakis, M., Spencer, L., Lewis, C., Hui, R., Blinman, P., Clarke, S., Boyer, M., Vardy, J. (2017). Impact of physical activity on fatigue and quality of life in people with advanced lung cancer: A randomized controlled trial. Annals of Oncology, 28(8), 1889-1897. [More Information]

Tio, M., Tsui, P., Fischer, G., Clarke, S. (2017). Osimertinib induced bullous dermatitis. Cancer Treatment and Research Communications, 13, 25-26. [More Information]

Chan, D., Clarke, S., Diakos, C., Roach, P., Bailey, D., Singh, S., Pavlakis, N. (2017). Prognostic and predictive biomarkers in neuroendocrine tumours. Critical Reviews in Oncology/Hematology, 113, 268-282. [More Information]

Itchins, M., Arena, J., Nahm, C., Rabindran, J., Kim, S., Gibbs, E., Bergamin, S., Chua, T., Gill, A., Maher, R., Diakos, C., Mittal, A., Hruby, G., Kneebone, A., Pavlakis, N., Samra, J., Clarke, S., et al (2017). Retrospective cohort analysis of neoadjuvant treatment and survival in resectable and borderline resectable pancreatic ductal adenocarcinoma in a high volume referral centre. European Journal of Surgical Oncology, 43(9), 1711-1717. [More Information]

van Zandwijk, N., Pavlakis, N., Kao, S., Linton, A., Boyer, M., Clarke, S., Huynh, Y., Chrzanowska, A., Fulham, M., Bailey, D., Cooper, W., Kritharides, L., Reid, G., et al (2017). Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study. The Lancet Oncology, 18(10), 1386-1396. [More Information]

Selinger, C., Li, B., Pavlakis, N., Links, M., Gill, A., Lee, A., Clarke, S., Tran, T., Lum, T., Yip, P., Horvath, L., Yu, B., O’Toole, S., Cooper, W., et al (2017). Screening for ROS1 gene rearrangements in non-small-cell lung cancers using immunohistochemistry with FISH confirmation is an effective method to identify this rare target. Histopathology, 70(3), 402-411. [More Information]

Lee, A., Chan, D., Wong, M., Li, B., Lumba, S., Clarke, S., Samra, J., Pavlakis, N. (2017). Systematic Review of the Role of Targeted Therapy in Metastatic Neuroendocrine Tumors. Neuroendocrinology, 104(3), 209-222. [More Information]

Chan, J., Chan, D., Diakos, C., Engel, A., Pavlakis, N., Gill, A., Clarke, S. (2017). The Lymphocyte-to-Monocyte Ratio is a Superior Predictor of Overall Survival in Comparison to Established Biomarkers of Resectable Colorectal Cancer. Annals of Surgery, 265(3), 539-546. [More Information]

Itchins, M., Chia, P., Hayes, S., Howell, V., Gill, A., Cooper, W., John, T., Mitchell, P., Millward, M., Clarke, S., Pavlakis, N., et al (2017). Treatment of ALK-rearranged non-small cell lung cancer: A review of the landscape and approach to emerging patterns of treatment resistance in the Australian context. Asia-Pacific Journal of Clinical Oncology, 13 Suppl 3, 3-13. [More Information]

Kao, S., Kirschner, M., Cooper, W., Tran, T., Burgers, S., Wright, C., Korse, T., van den Broek, D., Edelman, J., Vallely, M., McCaughan, B., Pavlakis, N., Clarke, S., van Zandwijk, N., Reid, G., et al (2016). A proteomics-based approach identifies secreted protein acidic and rich in cysteine as a prognostic biomarker in malignant pleural mesothelioma. British Journal of Cancer, 114(5), 524-531. [More Information]

Vaccaro, L., Johnson, S., Kiely, B., Clayton, J., Clarke, S., Beale, P., Silvester, W., Detering, K., Butow, P., Tattersall, M. (2016). Acceptability of tailored life-expectancy information in patients with advanced cancer participating in an Australian nurse-led ACP RCT. The 43nd Clinical Oncological Society of Australia Annual Scientific Meeting, .

Johnson, S., Clayton, J., Butow, P., Silvester, W., Detering, K., Hall, J., Kiely, B., Cebon, J., Clarke, S., Bell, M., Stockler, M., Tattersall, M., et al (2016). Advance care planning in patients with incurable cancer: Study protocol for a randomised controlled trial. BMJ Open, 6(12), 1-10. [More Information]

Song, X., Amirkhani, A., Wu, J., Pascovici, D., Zaw, T., Xavier, D., Clarke, S., Molloy, M. (2016). Analytical performance of nano-LC-SRM using nondepleted human plasma over an 18-month period. Proteomics, 16(15-16), 2118-2127. [More Information]

Reid, G., Kao, S., Pavlakis, N., Brahmbhatt, H., MacDiarmid, J., Clarke, S., Boyer, M., van Zandwijk, N. (2016). Clinical development of TargomiRs, a miRNA mimic-based treatment for patients with recurrent thoracic cancer. Epigenomics, 8(8), 1079-1085. [More Information]

Sclafani, F., Kim, T., Cunningham, D., Kim, T., Tabernero, J., Schmoll, H., Roh, J., Kim, S., Park, Y., Guren, T., Clarke, S., et al (2016). Dalotuzumab in chemorefractory KRAS exon 2 mutant colorectal cancer: Results from a randomised phase II/III trial. International Journal of Cancer, 140(2), 431-439. [More Information]

Hayes, S., Haefliger, S., Harris, B., Pavlakis, N., Clarke, S., Molloy, M., Howell, V. (2016). Exhaled breath condensate for lung cancer protein analysis: a review of methods and biomarkers. Journal of Breath Research, 10(3), 1-26. [More Information]

Vardy, J., Dhillon, H., Pond, G., Renton, C., Dodd, A., Zhang, H., Clarke, S., Tannock, I. (2016). Fatigue in people with localized colorectal cancer who do and do not receive chemotherapy: a longitudinal prospective study. Annals of Oncology, 27(9), 1761-1767. [More Information]

Oh, B., Figtree, G., Costa, D., Eade, T., Hruby, G., Lim, S., Elfiky, A., Martine, N., Rosenthal, D., Clarke, S., Back, M. (2016). Oxidative stress in prostate cancer patients: A systematic review of case control studies. Prostate International, 4(3), 71-87. [More Information]

Bailey, D., Lee, A., Li, B., Clarke, S. (2016). PET monitoring of liver directed selective internal radionuclide therapy for metastatic gastro-oesophageal cancer. BMJ Case Reports, 2016, bcr2016215645. [More Information]

Lane, R., Khin, N., Rogan, C., Magnussen, J., Pavlakis, N., Lane, D., Clarke, S. (2016). Safety and Feasibility of Repeatable Hepatic Vascular Isolation Chemotherapy: A Pilot Study. Annals of Surgical Oncology, 23(11), 3699-3708. [More Information]

Dong, S., Costa, D., Butow, P., Lovell, M., Agar, M., Velikova, G., Teckle, P., Tong, A., Tebbutt, N., Clarke, S., King, M., et al (2016). Symptom Clusters in Advanced Cancer Patients: An Empirical Comparison of Statistical Methods and the Impact on Quality of Life. Journal of Pain and Symptom Management, 51(1), 88-98. [More Information]

Wong, M., Chan, D., Lee, A., Li, B., Lumba, S., Clarke, S., Samra, J., Pavlakis, N. (2016). Systematic Review and Meta-Analysis on the Role of Chemotherapy in Advanced and Metastatic Neuroendocrine Tumor (NET). PloS One, 11(6), 1-15. [More Information]

Charles (nee Slaviero), K., Harris, B., Haddad, C., Clarke, S., Guminski, A., Stevens, M., Dodds, T., Gill, A., Back, M., Veivers, D., Eade, T. (2016). Systemic inflammation is an independent predictive marker of clinical outcomes in mucosal squamous cell carcinoma of the head and neck in oropharyngeal and nonoropharyngeal patients. BMC Cancer, 16(1), 1-13. [More Information]

Li, B., Barnes, T., Chan, D., Naidoo, J., Lee, A., Khasraw, M., Marx, G., Kris, M., Clarke, S., Drilon, A., Pavlakis, N., et al (2016). The addition of anti-angiogenic tyrosine kinase inhibitors to chemotherapy for patients with advanced non-small-cell lung cancers: A meta-analysis of randomized trials. Lung Cancer, 102, 21-27. [More Information]

Kao, S., Fulham, M., Wong, K., Cooper, W., Brahmbhatt, H., MacDiarmid, J., Pattison, S., Sagong, J., Huynh, Y., Leslie, F., Pavlakis, N., Clarke, S., Boyer, M., Reid, G., van Zandwijk, N. (2015). A significant metabolic and radiological response after a novel targeted microRNA-based treatment approach in malignant pleural mesothelioma. American Journal of Respiratory and Critical Care Medicine, 191(12), 1467-1469. [More Information]

Furtado, R., Ha, L., Clarke, S., Sandroussi, C. (2015). Adjuvant Iodine (131) Lipiodol after Resection of Hepatocellular Carcinoma. Journal of Oncology, 2015, 1-7. [More Information]

Diakos, C., Charles (nee Slaviero), K., Chua, W., Howell, V., Clarke, S. (2015). Biomarkers in Metastatic Colorectal Cancer. In Victor R. Preedy and Vinood B. Patel (Eds.), Biomarkers in Cancer, (pp. 601-629). Dordrecht: Springer. [More Information]

Vardy, J., Dhillon, H., Pond, G., Rourke, S., Bekele, T., Renton, C., Dodd, A., Zhang, H., Beale, P., Clarke, S., et al (2015). Cognitive Function in Patients With Colorectal Cancer Who Do and Do Not Receive Chemotherapy: A Prospective, Longitudinal, Controlled Study. Journal of Clinical Oncology, 33(34), 4085-4092. [More Information]

Park, W., Li, B., Maher, R., Samra, J., Clarke, S., Bernard, E., Bailey, D., Pavlakis, N. (2015). Dramatic response to selective internal radiation therapy for unresectable hepatocellular carcinoma. Oxford Medical Case Reports, 2015 (2), 194-195. [More Information]

Kao, S., van Zandwijk, N., Clarke, S., Vardy, J., Lumba, S., Tognela, A., Ng, W. (2015). Estimation of an optimal chemotherapy utilization rate for malignant pleural mesothelioma: An evidence-based benchmark for cancer care. Asia-Pacific Journal of Clinical Oncology, 11, 85-92. [More Information]

Ip, J., Pang, T., Glover, A., Soon, P., Zhao, J., Clarke, S., Robinson, B., Gill, A., Sidhu, S. (2015). Immunohistochemical validation of overexpressed genes identified by global expression microarrays in adrenocortical carcinoma reveals potential predictive and prognostic biomarkers. The Oncologist, 20(3), 247-256. [More Information]

Ip, J., Pang, T., Glover, A., Soon, P., Clarke, S., Richardson, A., Campbell, P., Robinson, B., Sidhu, S. (2015). Improving Outcomes in Adrenocortical Cancer: An Australian Perspective. Annals of Surgical Oncology, 22(7), 2309-2316. [More Information]

Zardawi, S., Li, B., Zauderer, M., Wang, J., Atmore, B., Barnes, T., Pavlakis, N., Mathur, M., Clarke, S. (2015). Localized malignant pleural mesothelioma with renal metastasis. Oxford Medical Case Reports, 2015 (1), 170-172. [More Information]

Glover, A., Zhao, J., Gill, A., Weiss, J., Mugridge, N., Kim, E., Feeney, A., Ip, J., Reid, G., Clarke, S., Robinson, B., Sidhu, S., et al (2015). microRNA-7 as a tumor suppressor and novel therapeutic for adrenocortical carcinoma. Oncotarget, 6(34), 36675-36688. [More Information]

Michael, M., White, S., Abdi, E., Nott, L., Clingan, P., Zimet, A., Button, P., Gregory, D., Solomon, B., Dobrovic, A., Clarke, S., et al (2015). Multicenter randomized, open-label phase II trial of sequential erlotinib and gemcitabine compared with gemcitabine monotherapy as first-line therapy in elderly or ECOG PS two patients with advanced NSCLC. Asia-Pacific Journal of Clinical Oncology, 11(1), 4-14. [More Information]

Haddad, C., Guo, L., Clarke, S., Guminski, A., Back, M., Eade, T. (2015). Neutrophil-to-lymphocyte ratio in head and neck cancer. Journal of Medical Imaging and Radiation Oncology, 59(4), 514-519. [More Information]

Chan, D., Clarke, S., Gill, A., Chantrill, L., Samra, J., Li, B., Barnes, T., Nahar, K., Pavlakis, N. (2015). Pathogenic PALB2 mutation in metastatic pancreatic adenocarcinoma and neuroendocrine tumour: A case report. Molecular and Clinical Oncology, 3(4), 817-819. [More Information]

McLachlan, A., Clarke, S. (2015). Phytotherapies: Drug Interactions in Cancer. In Iqbal Ramzan (Eds.), Phytotherapies: Efficacy, Safety, and Regulation, (pp. 536-553). New Jersey: Wiley. [More Information]

Jankova, L., Dent, O., Molloy, M., Chan, C., Chapuis, P., Howell, V., Clarke, S. (2015). Reporting in studies of protein biomarkers of prognosis in colorectal cancer in relation to the REMARK guidelines. Proteomics – Clinical Applications, 9(11-12), 1078-1086. [More Information]

Mehta, S., de Reuver, P., Gill, P., Andrici, J., D’Urso, L., Mittal, A., Pavlakis, N., Clarke, S., Samra, J., Gill, A. (2015). Somatostatin Receptor SSTR-2a Expression Is a Stronger Predictor for Survival Than Ki-67 in Pancreatic Neuroendocrine Tumors. Medicine, 94(40), 1-6. [More Information]

Zhou, J., Belov, L., Chapuis, P., Chan, C., Armstrong, N., Kaufman (nee Alexander), K., Solomon, M., Clarke, S., Christopherson, R. (2015). Surface profiles of live colorectal cancer cells and tumor infiltrating lymphocytes from surgical samples correspond to prognostic categories. Journal of Immunological Methods, 416, 59-68. [More Information]

Tan, C., Read, J., Phan, V., Beale, P., Peat, J., Clarke, S. (2015). The relationship between nutritional status, inflammatory markers and survival in patients with advanced cancer: a prospective cohort study. Supportive Care in Cancer, 23(2), 385-391. [More Information]

Wang, F., Gill, A., Neale, M., Puttaswamy, V., Gananadha, S., Pavlakis, N., Clarke, S., Hugh, T., Samra, J. (2014). Adverse tumor biology associated with mesenterico-portal vein resection influences survival in patients with pancreatic ductal adenocarcinoma. Annals of Surgical Oncology, 21(6), 1937-1947. [More Information]

Davis, E., Oh, B., Butow, P., Mullan, B., Clarke, S. (2014). Cancer patient disclosure and patient-doctor communication of complementary and alternative medicine use: A systematic review. Forschende Komplementarmedizin, 21(1), 58-59. [More Information]

Diakos, C., Charles (nee Slaviero), K., McMillan, D., Clarke, S. (2014). Cancer-related inflammation and treatment effectiveness. The Lancet Oncology, 15(11), e493-e503. [More Information]

Vardy, J., Dhillon, H., Pond, G., Rourke, S., Xu, W., Dodd, A., Renton, C., Park, A., Bekele, T., Ringash, J., Clarke, S., et al (2014). Cognitive function and fatigue after diagnosis of colorectal cancer. Annals of Oncology, 25(12), 2404-2412. [More Information]

Kao, S., van Zandwijk, N., Clarke, S. (2014). Comment on ‘Existing prognostic models, but not neutrophil-to-lymphocyte ratio, are prognostic in malignant mesothelioma’. British Journal of Cancer, 111(12), 2376-2376. [More Information]

Chik, J., Zhou, J., Moh, E., Christopherson, R., Clarke, S., Molloy, M., Packer, N. (2014). Comprehensive glycomics comparison between colon cancer cell cultures and tumours: Implications for biomarker studies. Journal of Proteomics, 108, 146-162. [More Information]

Tsoli, M., Schweiger, M., Vanniasinghe, A., Painter, A., Zechner, R., Clarke, S., Robertson, G. (2014). Depletion of White Adipose Tissue in Cancer Cachexia Syndrome Is Associated with Inflammatory Signaling and Disrupted Circadian Regulation. PloS One, 9(3), e92966- 1–12. [More Information]

Kim, B., Li, B., Engel, A., Samra, J., Clarke, S., Norton, I., Li, A. (2014). Diagnosis of gastrointestinal bleeding: A practical guide for clinicians. World Journal of Gastrointestinal Pathophysiology, 5(4), 467-478. [More Information]

Oh, B., Butow, P., Boyle, F., Beale, P., Costa, D., Pavlakis, N., Bell, D., Davis, E., Choi, S., Lee, M., Clarke, S., et al (2014). Effects of Qigong on Quality of Life, Fatigue, Stress, Neuropathy, and Sexual Function in Women with Metastatic Breast Cancer: A Feasibility Study. International Journal of Physical Medicine & Rehabilitation, 2(4), 1-6. [More Information]

Li, M., Chan, D., Pavlakis, N., Kneebone, A., Bailey, D., Clarke, S. (2014). Enduring complete metabolic response in metastatic adenocarcinoma of the gastro-oesophageal junction. Oxford Medical Case Reports, 2014 (6), 105-106. [More Information]

Hudson, A., Weir, C., Moon, E., Harvie, R., Klebe, S., Clarke, S., Pavlakis, N., Howell, V. (2014). Establishing a panel of chemo-resistant mesothelioma models for investigating chemo-resistance and identifying new treatments for mesothelioma. Scientific Reports, 4, 1-11. [More Information]

Linton, A., Pavlakis, N., O’Connell, R., Soeberg, M., Kao, S., Clarke, S., Vardy, J., van Zandwijk, N. (2014). Factors associated with survival in a large series of patients with malignant pleural mesothelioma in New South Wales. British Journal of Cancer, 111(9), 1860-1869. [More Information]

Hayes, S., Hudson, A., Clarke, S., Molloy, M., Howell, V. (2014). From mice to men: GEMMs as trial patients for new NSCLC therapies. Seminars in Cell & Developmental Biology, 27, 118-127. [More Information]

Kohonen-Corish, M., Tseung, J., Chan, C., Currey, N., Dent, O., Clarke, S., Bokey, L., Chapuis, P. (2014). KRAS mutations and CDKN2A promoter methylation show an interactive adverse effect on survival and predict recurrence of rectal cancer. International Journal of Cancer, 134(12), 2820-2828. [More Information]

Sonpavde, G., Pond, G., Armstrong, A., Clarke, S., Vardy, J., Templeton, A., Wang, S., Paolini, J., Chen, I., Chow-Maneval, E., et al (2014). Prognostic Impact of the Neutrophil-to-Lymphocyte Ratio in Men With Metastatic Castration-Resistant Prostate Cancer. Clinical Genitourinary Cancer, 12(5), 317-324. [More Information]

Clarke, S. (2013). A Medical Oncology Approach to Colorectal Cancer. Cancer Nurses Society of Australia Educational Event 2011.

Hibbert, E., Lambert, T., Carter, J., Learoyd, D., Twigg, S., Clarke, S. (2013). A randomized controlled pilot trial comparing the impact of access to clinical endocrinology video demonstrations with access to usual revision resources on medical student performance of clinical endocrinology skills. BMC Medical Education, 13(1), 1-10. [More Information]

Clarke, S., Burge, M., Cordwell, C., Gibbs, P., Reece, W., Tebbutt, N. (2013). An Australian translational Study to evaluate the prognostic role of inflammatory markers in patients with metastatic ColorEctal caNcer Treated with bevacizumab (AvastinTM) [ASCENT]. BMC Cancer, 13, 1-7. [More Information]

Clarke, S. (2013). An Australian Translational Study to Evaluate the Prognostic Role of lnflammatorv Markers in Patients with Metastatic Colorectal Cancer Treated with Bevacizumab (Avastin TM ) [ASCENT]. 2012 COSA 39th Annual Scientific Meeting.

Toon, C., Walsh, M., Chou, A., Capper, D., Clarkson, A., Sioson, L., Clarke, S., Mead, S., Walters, R., Clendenning, M., Gill, A., et al (2013). BRAFV600E Immunohistochemistry Facilitates Universal Screening of Colorectal Cancers for Lynch Syndrome. American Journal of Surgical Pathology, 37(10), 1592-1602. [More Information]

Elens, L., Nieuweboer, A., Clarke, S., Charles (nee Slaviero), K., De Graan, A., Haufroid, V., Mathijssen, R., Van Schaik, R. (2013). CYP3A4 intron 6 C>T SNP (CYP3A4*22) encodes lower CYP3A4 activity in cancer patients, as measured with probes midazolam and erythromycin. Pharmacogenomics, 14(2), 137-149. [More Information]

Kao, S., Lee, K., Klebe, S., Henderson, D., McCaughan, B., Vardy, J., Clarke, S., van Zandwijk, N. (2013). Excision Repair Cross Complementation Group 1 and Thymidylate Synthase Expression in Patients With Mesothelioma. Clinical Lung Cancer, 14(2), 164-171. [More Information]

Kacevska, M., Mahns, A., Sharma, R., Clarke, S., Robertson, G., Liddle, C. (2013). Extra-Hepatic Cancer Represses Hepatic Drug Metabolism Via Interleukin (IL)-6 Signalling. Pharmaceutical Research, 30(9), 2270-2278. [More Information]

Linton, A., Pond, G., Clarke, S., Vardy, J., Galsky, M., Sonpavde, G. (2013). Glasgow Prognostic Score As a Prognostic Factor in Metastatic Castration-Resistant Prostate Cancer Treated With Docetaxel-Based Chemotherapy. Clinical Genitourinary Cancer, 11(4), 423-430. [More Information]

Kao, S., Vardy, J., Harvie, R., Chatfield, M., van Zandwijk, N., Clarke, S., Pavlakis, N. (2013). Health-related quality of life and inflammatory markers in malignant pleural mesothelioma. Supportive Care in Cancer, 21(3), 697-705. [More Information]

Linton, A., Kao, S., Vardy, J., Clarke, S., van Zandwijk, N., Klebe, S. (2013). Immunohistochemistry in the diagnosis of malignant pleural mesothelioma: Trends in Australia and a literature review. Asia-Pacific Journal of Clinical Oncology, 9(3), 273-279. [More Information]

Elens, L., Nieuweboer, A., Clarke, S., Charles (nee Slaviero), K., De Graan, A., Haufroid, V., van Gelder, T., Mathijssen, R., Van Schaik, R. (2013). Impact of POR*28 on the clinical pharmacokinetics of CYP3A phenotyping probes midazolam and erythromycin. Pharmacogenetics and Genomics, 23(3), 148-155. [More Information]

Vardy, J., Dhillon, H., Clarke, S., Olesen, I., Leslie, F., Warby, A., Beith, J., Sullivan, A., Hamilton, A., Beale, P., Rittau, A., McLachlan, A. (2013). Investigation of herb-drug interactions with ginkgo biloba in women receiving hormonal treatment for early breast cancer. SpringerPlus, 2(1), 1-5. [More Information]

Clarke, S., Karapetis, C., Gibbs, P., Pavlakis, N., Desai, J., Michael, M., Tebbutt, N., Price, T., Tabernero, J. (2013). Overview of biomarkers in metastatic colorectal cancer: Tumour, blood and patient-related factors. Critical Reviews in Oncology / Hematology (online), 85(2), 121-135. [More Information]

Kao, S., Clarke, S., Vardy, J., Corte, P., Clarke, C., van Zandwijk, N. (2013). Patterns of care for malignant pleural mesothelioma patients compensated by the Dust Diseases Board in New South Wales, Australia. Internal Medicine Journal, 43(4), 402-410. [More Information]

Jankova, L., Dent, O., Chan, C., Chapuis, P., Clarke, S. (2013). Preoperative neutrophil/lymphocyte ratio predicts overall survival but does not predict recurrence or cancer-specific survival after curative resection of node-positive colorectal cancer. BMC Cancer, 13, 1-13. [More Information]

Stein, R., Sharpe, L., Bell, M., Boyle, F., Dunn, S., Clarke, S. (2013). Randomized Controlled Trial of a Structured Intervention to Facilitate End-of-Life Decision Making in Patients With Advanced Cancer. Journal of Clinical Oncology, 31(27), 3403-3410. [More Information]

Hasovits, C., Pavlakis, N., Howell, V., Gill, A., Clarke, S. (2013). Resistance to EGFR targeted antibodies – expansion of clones present from the start of treatment. The more things change, the more they stay the same (Plus ca change, plus ca ne change pas!). Translational Gastrointestinal Cancer, 28(1), 44-46. [More Information]

Guthrie, G., Charles (nee Slaviero), K., Roxburgh, C., Horgan, P., McMillan, D., Clarke, S. (2013). The systemic inflammation-based neutrophil-lymphocyte ratio: Experience in patients with cancer. Critical Reviews in Oncology / Hematology (online), 88(1), 218-230. [More Information]

Findlay, M., Bauer, J., Clarke, S., Isenring, E. (2013). Understanding nutritional issues in the older person with cancer. Cancer Forum, 37(3), 234-237.

Kao, S., van Zandwijk, N., Corte, P., Clarke, C., Clarke, S., Vardy, J. (2013). Use of cancer therapy at the end of life in patients with malignant pleural mesothelioma. Supportive Care in Cancer, 21(7), 1879-1884. [More Information]

Kao, S., Vardy, J., Chatfield, M., Corte, P., Pavlakis, N., Clarke, C., van Zandwijk, N., Clarke, S. (2013). Validation of Prognostic Factors in Malignant Pleural Mesothelioma: A Retrospective Analysis of Data from Patients Seeking Compensation from the New South Wales Dust Diseases Board. Clinical Lung Cancer, 14(1), 70-77. [More Information]

de Marinis, F., Clarke, S. (2013). Vitamin supplementation in patients receiving pemetrexed for advanced non-small cell lung cancer. Lung Cancer, 82(3), 511-511. [More Information]

Oh, B., Butow, P., Mullan, B., Hale, A., Lee, M., Guo, X., Clarke, S. (2012). A Critical Review of the Effects of Medical Qigong on Quality of Life, Immune Function, and Survival in Cancer Patients. Integrative Cancer Therapies, 11(2), 101-110. [More Information]

Proctor, M., McMillan, D., Morrison, D., Fletcher, C., Horgan, P., Clarke, S. (2012). A derived neutrophil to lymphocyte ratio predicts survival in patients with cancer. British Journal of Cancer, 107(4), 695-699. [More Information]

Michael, M., Pavlakis, N., Clingan, P., de Boer, R., Johnston, M., Clarke, S. (2012). A multi-centre randomized, open-label phase II trial of continuous erlotinib plus gemcitabine or gemcitabine as first-line therapy in ECOG PS2 patients with advanced non-small cell lung cancer. Oncology Reports, 28(3), 763-767. [More Information]

Tsoli, M., Moore, M., Burg, D., Painter, A., Taylor, R., Lockie, S., Turner, N., Warren, A., Cooney, G., Oldfield, B., Clarke, S., et al (2012). Activation of Thermogenesis in Brown Adipose Tissue and Dysregulated Lipid Metabolism Associated with Cancer Cachexia in Mice. Cancer Research, 72(17), 4372-4382. [More Information]

De Gramont, A., Van Cutsem, E., Schmoll, H., Tabernero, J., Clarke, S., Moore, M., Cunningham, D., Cartwright, T., Hecht, J., Rivera, F., et al (2012). Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): a phase 3 randomised controlled trial. The Lancet Oncology, 13(12), 1225-1233. [More Information]

Bullen, T., Sharpe, L., Lawsin, C., Patel (nee Chauhan), D., Clarke, S., Bokey, E. (2012). Body image as a predictor of psychopathology in surgical patients with colorectal disease. Journal of Psychosomatic Research, 73(6), 459-463. [More Information]

Davis, E., Oh, B., Butow, P., Mullan, B., Clarke, S. (2012). Cancer Patient Disclosure and Patient-Doctor Communication of Complementary and Alternative Medicine Use: A Systematic Review. The Oncologist, 17(11), 1475-1481. [More Information]

Clarke, S. (2012). Comparison of nutritional assessment with a new definition of cachexia in determining outcomes of advanced cancer patients. European Society of Medical Oncology 2012 Congress.

Shum, A., Mahendradatta, T., Taylor, R., Painter, A., Moore, M., Tsoli, M., Tan, T., Clarke, S., Robertson, G., Polly, P. (2012). Disruption of MEF2C signaling and loss of sarcomeric and mitochondrial integrity in cancer-induced skeletal muscle wasting. Aging, 4(2), 133-143. [More Information]

Michael, M., Cullinane, C., Hatzimihalis, A., O’Kane, C., Milner, A., Booth, R., Schlicht, S., Clarke, S., Francis, P. (2012). Docetaxel pharmacokinetics and its correlation with two in vivo probes for cytochrome P450 enzymes: the C(14)-erythromycin breath test and the antipyrine clearance test. Cancer Chemotherapy and Pharmacology, 69(1), 125-135. [More Information]

Oh, B., Butow, P., Mullan, B., Clarke, S., Beale, P., Pavlakis, N., Lee, M., Rosenthal, D., Larkey, L., Vardy, J. (2012). Effect of Medical Qigong on Cognitive function, Quality of Life and a Biomarker of Inflammation in Cancer Patients: A Randomized Controlled Trial. Supportive Care in Cancer, 20(6), 1235-1242. [More Information]

Jankova, L., Robertson, G., Chan, C., Tan, K., Kohonen-Corish, M., Fung, C., Clarke, C., Lin, B., Molloy, M., Chapuis, P., Bokey, E., Dent, O., Clarke, S. (2012). Glutathione S-transferase Pi expression predicts response to adjuvant chemotherapy for stage C colon cancer: a matched historical control study. BMC Cancer, 12, 1-9. [More Information]

Linton, A., van Zandwijk, N., Reid, G., Clarke, S., Cao, C., Kao, S. (2012). Inflammation in malignant mesothelioma – friend or foe? Annals of Cardiothoracic Surgery, 1(4), 516-522. [More Information]

Clarke, S., McLachlan, A. (2012). Interaction Between Complementary and Alternative Medicines and Conventional Medicines. In Olver, I and Robotin, M (Eds.), Perspectives on Complementary and Alternative Medicines, (pp. 227-259). London: Imperial College Press. [More Information]

Clarke, S. (2012). Lower Gastrointestinal Cancers Update. 2012 Roche Products Adelaide Post-ASCO Education Meeting.

Kho, P., Jankova, L., Fung, C., Chan, C., Clarke, C., Lin, B., Robertson, G., Molloy, M., Chapuis, P., Bokey, E., Dent, O., Clarke, S. (2012). Overexpression of protein S100A4 is independently associated with overall survival in stage C colonic cancer but only in cytoplasm at the advancing tumour front. International Journal of Colorectal Disease, 27(11), 1409-1417. [More Information]

Van Der Wall, H., Elison, B., Frater, C., Bruce, W., Clarke, S. (2012). Pathophysiology of Bone Metastases. In Ignac Fogelman, Gopinath Gnanasegaran, Hans Van der Wall. (Eds.), Radionuclide and Hybrid Bone Imaging, (pp. 59-84). Heidelberg: Springer. [More Information]

Hasovits, C., Clarke, S. (2012). Pharmacokinetics and Pharmacodynamics of Intraperitoneal Cancer Chemotherapeutics. Clinical Pharmacokinetics, 51(4), 203-224. [More Information]

Clarke, S. (2012). Plasma biomarkers of outcome in CRC. Merck Serono Australia Tailored Therapies Meeting- The New Era- Focus on Colorectal Cancer.

Clarke, S. (2012). Predictive and prognostics factors associated with Mesothelioma and Lung Cancer. Lilly Oncology Australian Scientific Exchange Meeting 2012.

Clarke, S. (2012). Prognostic Factors in Colorectal Cancer. Roche Haematology & Oncology Targeted Therapies (HOTT) Symposium 2012.

Randall, S., McKay, M., Pascovici, D., Mahon, K., Horvath, L., Clarke, S., Molloy, M. (2012). Remarkable temporal stability of high-abundance human plasma proteins assessed by targeted mass spectrometry. Proteomics – Clinical Applications, 6(11-12), 626-634. [More Information]

Chua, W., Horvath, L., Beale, P., Clarke, S. (2012). Reporting clinical trial information: colorectal cancer trials at Sydney Cancer Centre. Internal Medicine Journal, 42(4), 416-421. [More Information]

Chellappa, K., Jankova, L., Schnabl, J., Pan, S., Brelivet, Y., Fung, C., Chan, C., Dent, O., Clarke, S., Robertson, G., et al (2012). Src tyrosine kinase phosphorylation of nuclear receptor HNF4a correlates with isoform-specific loss of HNF4a in human colon cancer. Proceedings of the National Academy of Sciences of the United States of America, 109(7), 2302-2307. [More Information]

Chua, W., Clarke, S., Charles (nee Slaviero), K. (2012). Systemic inflammation and prediction of chemotherapy outcomes in patients receiving docetaxel for advanced cancer. Supportive Care in Cancer, 20(8), 1869-1874. [More Information]

Clarey, J., Kao, S., Clarke, S., Vardy, J. (2012). The eligibility of advanced non-small-cell lung cancer patients for targeted therapy clinical trials. Annals of Oncology, 23(5), 1229-1233. [More Information]

Dhillon, H., Van Der Ploeg, H., Bell, M., Boyer, M., Clarke, S., Vardy, J. (2012). The impact of physical activity on fatigue and quality of life in lung cancer patients: A randomised controlled trial protocol. BMC Cancer, 12, 1-9. [More Information]

Kao, S., Harvie, R., Paturi, F., Taylor, R., Davey, R., Abraham, R., Clarke, S., Marx, G., Cullen, M., Kerestes, Z., Pavlakis, N. (2012). The predictive role of serum VEGF in an advanced malignant mesothelioma patient cohort treated with thalidomide alone or combined with cisplatin/gemcitabine. Lung Cancer, 75(2), 248-254. [More Information]

Linton, A., Vardy, J., Clarke, S., van Zandwijk, N. (2012). The ticking time-bomb of asbestos: Its insidious role in the development of malignant mesothelioma. Critical Reviews in Oncology / Hematology (online), 84(2), 200-212. [More Information]

Clarke, S. (2012). Translational research at the Kolling Institute of Medical Research. 5th Annual Hunter Cancer Research Symposium.

Kho, P., Chapuis, P., Beale, P., Bokey, E., Dent, O., Clarke, S. (2012). Use of adjuvant chemotherapy in stage C (III) rectal cancer: Comparison of data from matched patients in a teaching hospital’s clinico-pathological database. Asia-Pacific Journal of Clinical Oncology, 8(4), 346-355. [More Information]

Clarke, S. (2012). What are a treating team’s obligations to ensure access to treatment and compensation for mesothelioma sufferers? 4th Australian Lung Cancer Conference.

Kao, S., Yan, T., Lee, K., Burn, J., Henderson, D., Klebe, S., Kennedy, C., Vardy, J., Clarke, S., Van Zandwijk, N., et al (2011). Accuracy of diagnostic biopsy for the histological subtype of malignant pleural mesothelioma. Journal of Thoracic Oncology, 6(3), 602-605. [More Information]

Phan, V., Tan, C., Rittau, A., Xu, H., McLachlan, A., Clarke, S. (2011). An update on ethnic differences in drug metabolism and toxicity from anti-cancer drugs. Expert Opinion on Drug Metabolism and Toxicology, 7(11), 1395-1410. [More Information]

Clarke, S. (2011). Bone Metastases. Nuclear Medicine Society NSW Educational Meeting.

Clarke, S. (2011). Cancer in Northern Sydney. Kolling Institute of Medical Research Public Forum “Our Fight Against Cancer”.

Fung, D., Lo, A., Jankova, L., Clarke, S., Molloy, M., Robertson, G., Wilkins, M. (2011). Classification of Cancer Patients Using Pathway Analysis and Network Clustering. In Gerard Cagney, Andrew Emili (Eds.), Network Biology: Methods and Applications, (pp. 311-336). New York: Humana Press.

He, X., Clarke, S., McLachlan, A. (2011). Clinical pharmacology of chemotherapy agents in older people with cancer. Current Gerontology and Geriatrics Research, 2011, 628670-1-628670-6. [More Information]

Chua, W., Kho, P., Moore, M., Charles (nee Slaviero), K., Clarke, S. (2011). Clinical, laboratory and molecular factors predicting chemotherapy efficacy and toxicity in colorectal cancer. Critical Reviews in Oncology/Hematology, 79(3), 224-250. [More Information]

Tan, K., Jankova, L., Chan, C., Fung, C., Clarke, C., Lin, B., Robertson, G., Molloy, M., Chapuis, P., Bokey, E., Clarke, S., et al (2011). Clinicopathological correlates and prognostic significance of glutathione S-transferase Pi expression in 468 patients after potentially curative resection of node-positive colonic cancer. Histopathology, 59(6), 1057-1070. [More Information]

Zhou, J., Belov, L., Solomon, M., Chan, C., Clarke, S., Christopherson, R. (2011). Colorectal cancer cell surface protein profiling using an antibody microarray and fluorescence multiplexing. Journal of Visualized Experiments, (55), 1-6. [More Information]

Kacevska, M., Downes, M., Sharma, R., Evans, R., Clarke, S., Liddle, C., Robertson, G. (2011). Extrahepatic Cancer Suppresses Nuclear Receptor-Regulated Drug Metabolism. Clinical Cancer Research, 17(10), 3170-3180. [More Information]

Clarke, S., McLachlan, A. (2011). Interaction between complementary and alternative medicine with conventional anti-cancer medicine. Cancer Forum, 35(1), 18-23.

Lee, A., Chick, J., Kolarich, D., Haynes, P., Robertson, G., Tsoli, M., Jankova, L., Clarke, S., Packer, N., Baker, M. (2011). Liver membrane proteome glycosylation changes in mice bearing an extra-hepatic tumour. Molecular and Cellular Proteomics, 10(9), 1-18. [More Information]

Kao, S., Klebe, S., Henderson, D., Reid, G., Chatfield, M., Armstrong, N., Yan, T., Vardy, J., Clarke, S., van Zandwijk, N., McCaughan, B. (2011). Low Calretinin Expression and High Neutrophil-To-Lymphocyte Ratio Are Poor Prognostic Factors in Patients with Malignant Mesothelioma Undergoing Extrapleural Pneumonectomy. Journal of Thoracic Oncology, 6(11), 1923-1929. [More Information]

Chua, W., Charles (nee Slaviero), K., Baracos, V., Clarke, S. (2011). Neutrophil/lymphocyte ratio predicts chemotherapy outcomes in patients with advanced colorectal cancer. British Journal of Cancer, 104(8), 1288-1295. [More Information]

Backshall, A., Sharma, R., Clarke, S., Keun, H. (2011). Pharmacometabonomic profiling as a predictor of toxicity in patients with inoperable colorectal cancer treated with capecitabine. Clinical Cancer Research, 17(9), 3019-3028. [More Information]

Clarke, S. (2011). Plenary address: Cancer Research at the Universitv of Sydney. Cancer Research Network Postgraduate Symposium 2011.

Clarke, S. (2011). Predicting outcomes in Lung Cancer. The Second Oncology Forum of Chinese Physicians from China and the US (OFCCU).

Clarke, S. (2011). Predicting outcomes of cancer treatment. 2011 ARCS Scientific Congress.

Jankova, L., Chan, C., Fung, C., Song, X., Kwun, S., Cowley, M., Kaplan, W., Dent, O., Bokey, E., Chapuis, P., Robertson, G., Clarke, S., et al (2011). Proteomic comparison of colorectal tumours and non-neoplastic mucosa from paired patient samples using iTRAQ mass spectrometry. Molecular BioSystems, 7(11), 2997-3005. [More Information]

Mitchell, P., Broad, A., Rosenthal, M., Galettis, P., Abraham, R., Burns, I., Clarke, S., Milner, A., Diiulio, J., Links, M. (2011). Randomized phase 2 sequencing and pharmacokinetic study of gemcitabine and oxaliplatin in advanced non-small cell lung cancer. Asia-Pacific Journal of Clinical Oncology, 7(4), 376-384. [More Information]

Oh, B., Hu, G., Kao, S., Gebski, V., Walls, R., Truong, L., Beale, P., Clarke, S. (2011). Safety and tolerability of Chinese Herbal Medicine with cancer patients receiving chemotherapy. WebmedCentral, 2(Article ID: WMC001671), 1-11.

Clarke, S., Yip, S., Brown, C., van Hazel, G., Ransom, D., Goldstein, D., Jeffrey, G., Tebbutt, N., Buck, M., Lowenthal, R., Boland, A., Gebski, V., Simes, R., et al (2011). Single-agent irinotecan or 5-fluorouracil and leucovorin (FOLFIRI) as second-line chemotherapy for advanced colorectal cancer; results of a randomised phase II study (DaVINCI) and meta-analysis. European Journal of Cancer, 47(12), 1826-1836. [More Information]

Clarke, S. (2011). Successes, challenges and future directions. In Dimitrios H Roukos (Eds.), Advances in Personalized Cancer Management, (pp. 84-95). London: Future Medicine Ltd.

Leighl, N., Shepherd, H., Butow, P., Clarke, S., McJannett, M., Beale, P., Wilcken, N., Moore, M., Chen, E., Goldstein, D., Horvath, L., Tattersall, M., et al (2011). Supporting Treatment Decision Making in Advanced Cancer: A Randomized Trial of a Decision Aid for Patients With Advanced Colorectal Cancer Considering Chemotherapy. Journal of Clinical Oncology, 29(15), 2077-2084. [More Information]

Sharpe, L., Patel (nee Chauhan), D., Clarke, S. (2011). The relationship between body image disturbance and distress in colorectal cancer patients with and without stomas. Journal of Psychosomatic Research, 70(5), 395-402. [More Information]

Clarke, S. (2011). Update on Neuroendocrine. Endocrine and Oncology Nurses of Australia Symposium.

Clarke, S., Chua, W., Moore, M., Kao, S., Phan, V., Tan, C., Charles (nee Slaviero), K., McMillan, D. (2011). Use of inflammatory markers to guide cancer treatment. Clinical Pharmacology & Therapeutics, 90(3), 475-478. [More Information]

Clarke, S. (2011). Use of the neutrophil lymphocyte ratio to predict outcomes from chemotherapy. Medical Oncology Group of Australia Limited Annual Scientific Meeting 2011, Adelaide, South Australia: Medical Oncology Group of Australia.

Patel (nee Chauhan), D., Sharpe, L., Thewes, B., Bell, M., Clarke, S. (2011). Using the distress thermometer and hospital anxiety and depression scale to screen for psychosocial morbidity in patients diagnosed with colorectal cancer. Journal of Affective Disorders, 131(1-3), 412-416. [More Information]

Kao, S., Griggs, K., Lee, K., Armstrong, N., Clarke, S., Vardy, J., van Zandwijk, N., Burn, J., McCaughan, B., Henderson, D., et al (2011). Validation of a minimal panel of antibodies for the diagnosis of malignant pleural mesothelioma. Pathology, 43(4), 313-317. [More Information]

Kao, S., Lee, K., Armstrong, N., Clarke, S., Vardy, J., van Zandwijk, N., Reid, G., Burn, J., McCaughan, B., Henderson, D., et al (2011). Validation of tissue microarray technology in malignant pleural mesothelioma. Pathology, 43(2), 128-132. [More Information]

Cassidy, J., Clarke, S., Diaz-Rubio, E., Scheithauer, W., Figer, A., Wong, R., Koski, S., Rittweger, K., Gilberg, F., Saltz, L. (2011). XELOX vs FOLFOX-4 as first-line therapy for metastatic colorectal cancer: NO16966 updated results. British Journal of Cancer, 105(1 Spring 2010), 58-64. [More Information]

Blinman, P., Duric, V., Nowak, A., Beale, P., Clarke, S., Briscoe, K., Boyce, A., Goldstein, D., Hudson, M., Stockler, M. (2010). Adjuvant chemotherapy for early colon cancer: What survival benefits make it worthwhile? European Journal of Cancer, 46(10), 1800-1807. [More Information]

Clarke, S., McLachlan, A., Brown, D., Carbonara, S., Kissane, R. (2010). Beyond Conventional Cancer Treatments: The Use of Complementary Therapies During Cancer Treatment: Implications for Clinicians. In Monica Robotin, Ian Olver, Afaf Girgis (Eds.), When Cancer Crosses Disciplines: A Physicians Handbook, (pp. 285-315). London: Imperial College Press. [More Information]

Chua, W., Clarke, S. (2010). Clinical Trial Information As a Measure of Quality Cancer Care. Journal of Oncology Practice, 6(3), 170-171. [More Information]

Fung, C., Chan, C., Jankova, L., Dent, O., Robertson, G., Molloy, M., Bokey, E., Chapuis, P., Lin, B., Clarke, S. (2010). Clinicopathological correlates and prognostic significance of maspin expression in 450 patients after potentially curative resection of node-positive colonic cancer. Histopathology, 56(3), 319-330. [More Information]

Clarke, S. (2010). Evaluating Chemotherapy Toxicity/Antimetabolite Chemotherapy. Medical Oncology Group of Australia Basic Sciences of Oncology Program 2010.

Chan, C., Jankova, L., Fung, C., Clarke, C., Robertson, G., Chapuis, P., Bokey, E., Lin, B., Dent, O., Clarke, S. (2010). Fascin Expression Predicts Survival After Potentially Curative Resection of Node-positive Colon Cancer. American Journal of Surgical Pathology, 34(5), 656-666. [More Information]

Kao, S., Pavlakis, N., Harvie, R., Vardy, J., Boyer, M., van Zandwijk, N., Clarke, S. (2010). High blood neutrophil-to-lymphocyte ratio is an indicator of poor prognosis in malignant mesothelioma patients undergoing systemic therapy. Clinical Cancer Research, 16(23), 5805-5813. [More Information]

Lam, F., Jankova, L., Dent, O., Molloy, M., Kwun, S., Clarke, C., Chapuis, P., Robertson, G., Beale, P., Clarke, S., Bokey, E., Chan, C. (2010). Identification of distinctive protein expression patterns in colorectal adenoma. Proteomics – Clinical Applications, 4(1), 60-70. [More Information]

Oh, B., Butow, P., Mullan, B., Clarke, S., Beale, P., Pavlakis, N., Kothe, E., Lam, L., Rosenthal, D. (2010). Impact of Medical Qigong on quality of life, fatigue, mood and inflammation in cancer patients: a randomized controlled trial. Annals of Oncology, 21(3), 608-614. [More Information]

Moore, M., Chua, W., Charles (nee Slaviero), K., Clarke, S. (2010). Inflammation and Cancer: Causes and Consequences. Clinical Pharmacology & Therapeutics, 87(4), 504-508. [More Information]

Clarke, S. (2010). Interacting with Pharma. 2010 Joint MOGA and Private Cancer Physicians of Australia.

Kho, P., Chua, W., Moore, M., Clarke, S. (2010). Is it Prime Time for Personalized Medicine in Cancer Treatment? Personalized Medicine, 7(4), 387-397. [More Information]

Clarke, S. (2010). lndividualisation of Chemotherapy in Colorectal Cancer. Colorectal Cancer – A Multidisciplinary Approach Meeting.

Kao, S., Reid, G., Lee, K., Vardy, J., Clarke, S., van Zandwijk, N. (2010). Malignant Mesothelioma. International Medical Journal[More Information]

Clarke, S. (2010). Options in Academia. Pfizer Advanced Trainee Education Meeting.

Kao, S., Butow, P., Bray, V., Clarke, S., Vardy, J. (2010). Patient and oncologist estimates of survival in advanced cancer patients. Psycho-Oncology, 10(2), 213-218. [More Information]

Oh, B., Butow, P., Mullan, B., Clarke, S., Tattersall, M., Boyer, M., Beale, P., Vardy, J., Pavlakis, N., Larke, L. (2010). Patient-Doctor Communication: Use of Complementary and Alternative Medicine by Adult Patients with Cancer. Journal of the Society for Integrative Oncology, 8(2), 56-64. [More Information]

Kao, S., Phan, V., Clarke, S. (2010). Predictive Markers for Haematological Toxicity of Pemetrexed. Current Drug Targets, 11(1), 48-57. [More Information]

Clarke, S. (2010). Predictors of outcomes in colorectal cancer. Ludwig Institute Colon Cancer Symposium.

Zhou, J., Belov, L., Huang, P., Shin, J., Solomon, M., Chapuis, P., Bokey, E., Chan, C., Clarke, C., Clarke, S., Christopherson, R. (2010). Surface antigen profiling of colorectal cancer using antibody microarrays with fluorescence multiplexing. Journal of Immunological Methods, 355(40210 (1-2)), 40-51. [More Information]

Matic, M., Carradin, A., Tsoli, M., Clarke, S., Polly, P., Robertson, G. (2010). The alternatively spliced murine pregnane X receptor isoform, mPXRD171-211 exhibits a repressive action. The International Journal of Biochemistry and Cell Biology, 42(5), 672-682. [More Information]

Oh, B., Butow, P., Mullan, B., Beale, P., Pavlakis, N., Rosenthal, D., Clarke, S. (2010). The use and perceived benefits resulting from the use of complementary and alternative medicine by cancer patients in Australia. Asia-Pacific Journal of Clinical Oncology, 6(4), 342-349. [More Information]

Clarke, S. (2010). Updates in Medical Oncology. 2010 ARCS Australia Annual Scientific Congress.

Matic, M., Nakhel, S., Lehnert, A., Polly, P., Clarke, S., Robertson, G. (2009). A novel approach to investigate the subcellular distribution of nuclear receptors in vivo. Nuclear Receptor Signaling, 7, 1-7. [More Information]

Chapuis, P., Bokey, E., Clarke, S., Beale, P., Dent, O. (2009). Adjuvant chemotherapy for stage C colonic cancer in a multidisciplinary setting. ANZ Journal of Surgery, 79(10), 685-692. [More Information]

Clarke, S. (2009). Advanced colorectal cancer – where are we going? AstraZeneca Challenges in Gastroenterology Symposium.

Chua, W., Peters, M., Loneragan, R., Clarke, S. (2009). Cetuximab-Associated Pulmonary Toxicity. Clinical Colorectal Cancer, 8(2), 118-120. [More Information]

Clarke, S. (2009). Chemotherapy and timing of surgery. Australia & New Zealand Medical & Surgical Gastrointestinal Week 2009.

Vardy, J., Dadasovich, R., Beale, P., Boyer, M., Clarke, S. (2009). Eligibility of patients with advanced non-small cell lung cancer for phase III chemotherapy trials. BMC Cancer, 9, 1-6. [More Information]

Hong, P., Moore, M., McLachlan, A., Piquette-Miller, M., Xu, H., Clarke, S. (2009). Ethnic differences in drug metabolism and toxicity from chemotherapy. Expert Opinion on Drug Metabolism and Toxicology, 5(3), 243-257. [More Information]

Sharma, R., Cunningham, D., Smith, P., Robertson, G., Dent, O., Clarke, S. (2009). Inflammatory (B) symptoms are independent predictors of myelosuppression from chemotherapy in Non-Hodgkin Lymphoma (NHL) patients-analysis of data from a British National Lymphoma Investigation phase III trial comparing CHOP to PMitCEBO. BMC Cancer, 9, 153-1-153-10. [More Information]

Clarke, S. (2009). Interactions with cancer therapies. Clinical Oncological Society of Australia 36th Annual Scientific Meeting: Awareness, Access, Action.

Clarke, S. (2009). Managing complex/multiple focus disease areas & networks: the cancer experience. National Institute of Complementary Medicine 2009 National Symposium: Supporting health priorities & industry growth.

Chua, W., Goldstein, D., Lee, C., Dhillon, H., Michael, M., Mitchell, P., Clark, S., Iacopetta, B. (2009). Molecular markers of response and toxicity to FOLFOX chemotherapy in metastatic colorectal cancer. British Journal of Cancer, 101(6), 998-1004. [More Information]

Sobrero, A., Ackland, S., Clarke, S., Perez-Carrion, R., Chiara, S., Gapski, J., Mainwaring, P., Langer, B., Young, S. (2009). Phase IV Study of Bevacizumab in Combination with Infusional Fluorouracil, Leucovorin and Irinotecan (FOLFIRI) in First-Line Metastatic Colorectal Cancer. Oncology, 77(2), 113-119. [More Information]

Clarke, S. (2009). Plasma proteomic predictors of response and toxicitv in colorectal cancer patients receiving chemotherapy. 2nd Sino-Australian Symposium, N/A: N/A.

Chua, W., Moore, M., Charles (nee Slaviero), K., Clarke, S. (2009). Predictive biomarkers of clinical response to targeted antibodies in colorectal cancer. Current Opinion in Molecular Therapeutics, 11(6), 611-622. [More Information]

Clarke, S. (2009). Systemic therapy for Malignant Mesothelioma: An Overview. ANZAC Research Institute’s 8th Annual Symposium.

Chua, W., Moore, M., Beale, P., Clarke, S. (2009). Third-line Treatment Options for Metastatic Colorectal Cancer. Asia Pacific Journal of Oncology and Hematology, 1(1), 27-35.

Van Cutsem, E., Verslype, C., Beale, P., Clarke, S., Bugat, R., Rakhit, A., Fettner, S., Brennscheidt, U., Feyereislova, A., Delord, J. (2008). A phase lb dose-escalation study of erlotinib, capecitabine and oxaliplatin in metastatic colorectal cancer patients. Annals of Oncology, 19(2), 332-339. [More Information]

Saltz, L., Clarke, S., Diaz-Rubio, E., Scheithauer, W., Figer, A., Wong, R., Koski, S., Lichinitser, M., Yang, T., Rivera, F., et al (2008). Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. Journal of Clinical Oncology, 26(12), 2013-2019. [More Information]

Read, J., Clarke, S. (2008). Clinical Nutrition. In E. Bruera, I. Higginson, C. Ripamonti, C. von Gunten (Eds.), Palliative Medicine, (pp. 595-601). United Kingdom: Hodder Arnold. [More Information]

Clarke, S. (2008). DaVINCI Trial Update and Issues in 2nd line chemotherapy. 10th Annual Scientific Meeting of Australasian Gastro-Intestinal Trials Group.

Clarke, S. (2008). Differences in Chemotherapy. 1st Sino-Australian Symposium.

Sharma, R., Kacevska, M., London, R., Clarke, S., Liddle, C., Robertson, G. (2008). Downregulation of drug transport and metabolism in mice bearing extra-hepatic malignancies. British Journal of Cancer, 98(1), 91-97. [More Information]

Robertson, G., Liddle, C., Clarke, S. (2008). Inflammation and Altered Drug Clearance in Cancer: Transcriptional Repression of a Human CYP3A4 Transgene in Tumor-bearing Mice. Pharmacology and Therapeutics, 83(6), 894-897. [More Information]

Clarke, S. (2008). Inflammation and cancer drug metabolism. Sydney Cancer Conference 2008 (SCC2008), Sydney: University of Sydney.

Kacevska, M., Robertson, G., Clarke, S., Liddle, C. (2008). Inflammation and CYP3A4-mediated drug metabolism in advanced cancer: impact and implications for chemotherapeutic drug dosing. Expert Opinion on Drug Metabolism and Toxicology, 4(2), 137-149. [More Information]

Clarke, S. (2008). Inflammation, drug metabolism and chemotherapy toxicity. Hunter Medical Research Institute Conference on Translational Cancer Research.

Clarke, S. (2008). Inflammatory Response: An unrecognized source of variability in PK/PD of cancer chemotherapy. ASCPT 2008 Annual Meeting.

Clarke, S. (2008). Infusion vs bolus chemotherapy for colon cancer/Stage II Colon Cancer: Is adjuvant chemotherapy necessary? National Cancer Control Network 1st Asian Scientific Meeting.

Oh, B., Butow, P., Mullan, B., Clarke, S. (2008). Medical Qigong for cancer patients: Pilot study of impact on quality of life, side effects of treatment and inflammation. American Journal of Chinese Medicine, 36(3), 459-472. [More Information]

Clarke, S. (2008). New developments in the practice of lung cancer. The Oncology Forum of Chinese Physicians from China and the US (OFCCU).

Harrison, J., Solomon, M., Young, J., Meagher, A., Butow, P., Salkeld, G., Hruby, G., Clarke, S. (2008). Patient and physician preferences for surgical and adjuvant treatment options for rectal cancer. JAMA (formerly Archives Of Surgery), 143(4), 389-394. [More Information]

Haller, D., Cassidy, J., Clarke, S., Cunningham, D., Hoff, P., Rothenberg, M., Saltz, L., Allegra, C., et al (2008). Potential regional differences for the tolerability profiles of fluoropyrimidines. Journal of Clinical Oncology, 26(13), 2118-2123. [More Information]

Clarke, S. (2008). Predicting toxicity from chemotherapy. The Australian Health & Medical Research Congress 2008.

Cassidy, J., Clarke, S., Diaz-Rubio, E., Scheithauer, W., Figer, A., Wong, R., Koski, S., Lichinitser, M., Yang, T., Rivera, F., et al (2008). Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer. Journal of Clinical Oncology, 26(12), 2006-2012. [More Information]

Morgan, E., Goralski, K., Piquette-Miller, M., Renton, K., Robertson, G., Chaluvadi, M., Charles, K., Clarke, S., Kacevska, M., Liddle, C., et al (2008). Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer. Drug Metabolism and Disposition, 36(2), 205-216. [More Information]

Chua, W., Beale, P., Clarke, S., Leung, M. (2008). Retrospective review of mitomycin C use as third-line chemotherapy in metastatic colorectal cancer. Asia-Pacific Journal of Clinical Oncology, 4(3), 132-136. [More Information]

Zalcberg, J., Rosen, L., Abdi, E., Davis, I., Gutheil, J., Schnell, F., Cesano, A., Gayko, U., Chen, M., Clarke, S. (2008). Role of Palifermin in Fluorouracil-Based Therapy for Metastatic Colorectal Cancer. Journal of Clinical Oncology, 26(8), 1386-1387. [More Information]

Sharma, R., Zucknick, M., London, R., Kacevska, M., Liddle, C., Clarke, S. (2008). Systemic inflammatory response predicts prognosis in patients with advanced-stage colorectal cancer. Clinical Colorectal Cancer, 7(5), 331-337. [More Information]

Sharma, R., Hoskins, J., Rivory, L., Zucknick, M., London, R., Liddle, C., Clarke, S. (2008). Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients. Clinical Cancer Research, 14(3), 817-825. [More Information]

Li, K., Rivory, L., Hoskins, J., Sharma, R., Clarke, S. (2007). Altered deoxyuridine and thymidine in plasma following capecitabine treatment in colorectal cancer patients. British Journal of Clinical Pharmacology, 63(1), 67-74. [More Information]

Yeo, W., Boyer, M., Chung, H., Ong, S., Lim, R., Zee, B., Ma, B., Lam, K., Mo, F., Ng, E., Clarke, S., Beale, P., et al (2007). Irofulven as first line therapy in recurrent or metastatic gastric cancer: a phase II multicenter study by the Cancer Therapeutics Research Group (CTRG). Cancer Chemotherapy and Pharmacology, 59(3), 295-300. [More Information]

Clarke, S., Goldstein, D., Mitchell, P., Michael, M., Beale, P., Friedlander, M., Zalcberg, J., White, S. (2007). Modification of Leucovorin Dose Within a Simplified FOLFOX Regimen Improves Tolerability Without Compromising Efficacy. Clinical Colorectal Cancer, 6(8), 578-582. [More Information]

Chuah, B., Lim, R., Boyer, M., Ong, A., Wong, S., Kong, H., Millward, M., Clarke, S., Goh, B. (2007). Multi-centre phase II trial of Thalidomide in the treatment of unresectable hepatocellular carcinoma. Acta Oncologica, 46(2), 234-238. [More Information]

Li, K., Rivory, L., Clarke, S. (2007). Pemetrexed pharmacokinetics and pharmacodynamics in a phase I/II study of doublet chemotherapy with vinorelbine: implications for further optimisation of pemetrexed schedules. British Journal of Cancer, 97(8), 1071-1076. [More Information]

Harrison, J., Solomon, M., Young, J., Meagher, A., Hruby, G., Salkeld, G., Clarke, S. (2007). Surgical and oncology trials for rectal cancer: Who will participate? Surgery, 142(1), 94-101. [More Information]

McKay, M., Sherman, J., Laver, M., Baker, M., Clarke, S., Molloy, M. (2007). The development of multiple reaction monitoring assays for liver-derived plasma proteins. Proteomics – Clinical Applications, 1(12), 1570-1581. [More Information]

Leighl, N., Shepherd, H., Butow, P., Clarke, S., McJannett, M., Beale, P., Wilcken, N., Moore, M., Chen, E., Tattersall, M., Goldstein, D. (2007). When the goal is not cure: A randomized trial of a patient decision aid in advanced colorectal cancer. Journal of Clinical Oncology, 25(18S), 6509.

Sharma, R., Rivory, L., Beale, P., Ong, S., Horvath, L., Clarke, S. (2006). A phase II study of fixed-dose capecitabine and assessment of predictors of toxicity in patients with advanced/metastatic colorectal cancer. British Journal of Cancer, 94(7), 964-968. [More Information]

Tobin, P., Beale, P., Noney, L., Liddell, S., Rivory, L., Clarke, S. (2006). A pilot study on the safety of combining chrysin, a non-absorbable inducer of UGT1A1, and irinotecan (CPT-11) to treat metastatic colorectal cancer. Cancer Chemotherapy and Pharmacology, 57(3), 309-316. [More Information]

Mitchell, P., Goldstein, D., Michael, M., Beale, P., Friedlander, M., Zalcberg, J., White, S., Thomson, J., Clarke, S. (2006). Addition of gabapentin to a modified FOLFOX regimen does not reduce oxaliplatin-induced neurotoxicity. Clinical Colorectal Cancer, 6(2), 146-151. [More Information]

Nordman, I., Iyer, S., Joshua, A., Clarke, S. (2006). Advances in the adjuvant treatment of colorectal cancer. ANZ Journal of Surgery, 76(5), 373-380. [More Information]

Read, J., Choy, S., Beale, P., Clarke, S. (2006). An evaluation of the prevalence of malnutrition in cancer patients attending the outpatient oncology clinic. Asia-Pacific Journal of Clinical Oncology, 2(2), 80-86. [More Information]

Clarke, S., Sharma, R. (2006). Angiogenesis inhibitors in cancer – mechanisms of action. Australian Prescriber, 29(1), 9-12.

Stockler, M., Tattersall, M., Boyer, M., Clarke, S., Beale, P., Simes, R. (2006). Disarming the guarded prognosis: predicting survival in newly referred patients with incurable cancer. British Journal of Cancer, 94(2), 208-212. [More Information]

Sobrero, A., Ackland, S., Perez-Carrion, R., Chiara, S., Clarke, S., Giron, C., Langer, B., Zurlo, A., Young, S. (2006). Efficacy and safety of bevacizumab in combination with irinotecan and infusional 5-FU as first-line treatment for patients with metastatic colorectal cancer. 2006 American Society of Clinical Oncology (ASCO) Annual Meeting, United States: American Society of Clinical Oncology.

Read, J., Choy, S., Beale, P., Clarke, S. (2006). Evaluation of nutritional and inflammatory status of advanced colorectal cancer patients and its correlation with survival. Nutrition and Cancer: an international journal, 55(1), 78-85. [More Information]

Read, J., Beale, P., Volker, D., Smith, N., Childs, A., Clarke, S. (2006). Nutrition intervention using an eicosapentaenoic acid (EPA)-containing supplement in patients with advanced colorectal cancer. Effects on nutritional and inflammatory status: a phase II trial. Supportive Care in Cancer, 15(3), 301-307. [More Information]

Rosen, L., Abdi, E., Davis, I., Gutheil, J., Schnell, F., Zalcberg, J., Cesano, A., Gayko, U., Chen, M., Clarke, S. (2006). Palifermin Reduces the Incidence of Oral Mucositis in Patients With Metastatic Colorectal Cancer Treated With Fluorouracil-Based Chemotherapy. Journal of Clinical Oncology, 24, 5194-5200. [More Information]

Aggarwal, G., Glare, P., Clarke, S., Chapuis, P. (2006). Palliative and shared care concepts in patients with advanced colorectal cancer. ANZ Journal of Surgery, 76(3), 175-180. [More Information]

Charles (nee Slaviero), K., Rivory, L., Stockler, M., Beale, P., Beith, J., Boyer, M., Clarke, S. (2006). Predicting the toxicity of weekly docetaxel in advanced cancer. Clinical Pharmacokinetics, 45(6), 611-622. [More Information]

Michael, M., Goldstein, D., Clarke, S., Milner, A., Beale, P., Friedlander, M., Mitchell, P. (2006). Prognostic Factors Predictive of Response and Survival to a Modified FOLFOX Regimen: Importance of an Increased Neutrophil Count. Clinical Colorectal Cancer, 6(4), 297-304.

Michael, M., Thompson, M., Hicks, R., Mitchell, P., Ellis, A., Milner, A., Di Iulio, J., Scott, A., Gurtler, V., Clarke, S., Zalcberg, J., et al (2006). Relationship of Hepatic Functional Imaging to Irinotecan Pharmacokinetics and Genetic Parameters of Drug Elimination. Journal of Clinical Oncology, 24(26), 4228-4235. [More Information]

Li, K., Rivory, L., Clarke, S. (2006). Solid-phase extraction (SPE) techniques for sample preparation in clinical and pharmaceutical analysis: A brief overview. Current Pharmaceutical Analysis, 2(2), 95-102. [More Information]

Tobin, P., Clarke, S., Seale, J., Lee, S., Solomon, M., Aulds, S., Crawford, M., Gallagher, J., Eyers, T., Rivory, L. (2006). The in vitro metabolism of irinotecan (CPT-11) by carboxylesterase and beta-glucuronidase in human colorectal tumours. British Journal of Clinical Pharmacology, 62(1), 122-129. [More Information]

Ackland, S., Clarke, S., Beale, P., Peters, G. (2006). Thymidylate synthase inhibitors. Update on Cancer Therapeutics, 1(4), 403-427. [More Information]

Haller, D., Cassidy, J., Clarke, S., Cunningham, D., Van Cutsem, E., Hoff, P., Rothenberg, M., Saltz, L., Schmoll, H., Twelves, C. (2006). Tolerability of fluoropyrimidines appears to differ by region. 2006 ASCO Annual Meeting, United Kingdom: Oxford University Press.

Charles (nee Slaviero), K., Rivory, L., Brown, S., Liddle, C., Clarke, S., Robertson, G. (2006). Transcriptional repression of hepatic cytochrome P450 3A4 gene in the presence of cancer. Clinical Cancer Research, 12(24), 7492-7497. [More Information]

Clarke, S., Boyer, M., Millward, M., Underhill, C., Moylan, E., Yip, D., White, S., Childs, A., Beale, P., Latz, J., et al (2005). A phase I/II study of pemetrexed and vinorelbine in patients with non-small cell lung cancer. Lung Cancer, 49(3), 401-412. [More Information]

Goldstein, D., Mitchell, P., Michael, M., Beale, P., Friedlander, M., Zalcberg, J., White, S., Clarke, S. (2005). Australian experience of a modified schedule of FOLFOX with high activity and tolerability and improved convenience in untreated metastatic colorectal cancer patients. British Journal of Cancer, 92(5), 832-837. [More Information]

Sharpe, L., Butow, P., Smith, C., McConnell, D., Clarke, S. (2005). Changes in quality of life in patients with advanced cancer – Evidence of response shift and response restriction. Journal of Psychosomatic Research, 58(6), 497-504. [More Information]

Vardy, J., Clarke, S. (2005). Ewing”s sarcoma of the rectum: Are four cycles of chemotherapy enough? Reply. Journal of Clinical Oncology, 23(24), 5850-5850.

Sharma, R., Boyer, M., Clarke, S., Millward, M. (2005). Gefitinib in advanced non-small cell lung cancer. Internal Medicine Journal, 35(2), 77-82. [More Information]

Joshua, A., Cotroneo, A., Clarke, S. (2005). Humor and oncology. Journal of Clinical Oncology, 23(3), 645-648. [More Information]

Read, J., Beale, P., Horvath, L., Volker, D., Childs, A., Smith, N., Clarke, S. (2005). Impact of fish-oil supplement on nutritional parameters, inflammation and chemotherapy induced toxicity in colorectal cancer (CRC) patients receiving FOLFIRI – A pilot study. Journal of Clinical Oncology, 23(16S (supplement)), Abstract 8243 S789-S789.

Sharma, R., Tobin, P., Clarke, S. (2005). Management of chemotherapy-induced nausea, vomiting, oral mucositis, and diarrhoea. The Lancet Oncology, 6(2), 93-102. [More Information]

Read, J., Crockett, N., Volker, D., MacLennan, P., Choy, S., Beale, P., Clarke, S. (2005). Nutritional assessment in cancer: comparing the Mini-Nutritional Assessment (MNA) with the scored Patient-Generated Subjective Global Assessment (PGSGA). Nutrition and Cancer: an international journal, 53(1), 51-56. [More Information]

Li, K., Rivory, L., Clarke, S. (2005). Rapid quantitation of plasma 2′-deoxyuridine by high-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometry and its application to pharmacodynamic studies in cancer patients. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences, 820(1), 121-130. [More Information]

Joshua, A., Adams, D., McKenzie, P., Solomon, M., Clarke, S. (2005). Small blue cell tumors of the rectum. Case 2. Small-cell carcinoma of the rectum. Journal of Clinical Oncology, 23(4), 912-3. [More Information]

Sharma, R., McLeod, D., Clarke, S. (2005). Small blue cell tumors of the rectum. Case 3. Atypical carcinoid of the rectum. Journal of Clinical Oncology, 23(4), 914-5. [More Information]

Vardy, J., Joshua, A., Clarke, S., Yarrow, P., Lin, B. (2005). Small blue cell tumors of the rectum: CASE 1. Ewing’s sarcoma of the rectum. Journal of Clinical Oncology, 23(4), 910-912. [More Information]

Joshua, A., Adams, D., McKenzie, P., Solomon, M., Clarke, S. (2005). Small Blue Cell Tumors of the Rectum: CASE 2. Small-Cell Carcinoma of the Rectum. Journal of Clinical Oncology, 23(4), 912-913. [More Information]

Sharma, R., McLeod, D., Clarke, S. (2005). Small Blue Cell Tumors of the Rectum: CASE 3. Atypical Carcinoid of the Rectum. Journal of Clinical Oncology, 23(4), 914-915. [More Information]

Joshua, A., Boyer, M., Subramanian, R., Clarke, S. (2005). Smoking reduction does work: resulting alterations in the incidence and histological subtypes of lung cancer in New South Wales in the last 20 years. Respirology, 10(2), 233-238. [More Information]

Tobin, P., Seale, P., Lee, S., Solomon, M., Fields, S., Rivory, L., Clarke, S. (2005). The in vitro metabolism of irinotecan (CPT-11) by carboxylesterase and beta-glucuronidase in human colorectal tumours. 2005 American Society of Clinical Oncology (ASCO) Annual Meeting, United States: American Society of Clinical Oncology.

Sharpe, L., Butow, P., Smith, C., McConnell, D., Clarke, S. (2005). The relationship between available support, unmet needs and caregiver burden in patients with advanced cancer and their carers. Psycho-Oncology, 14(2), 102-114. [More Information]

Clarke, S., Boyer, M., Stockler, M., Venkatawaran, R., Nordman, I., Joshua, A. (2005). Weekly docetaxel as second line treatment after mitoxantrone for androgen-independent prostate cancer (AIPC). 2005 ASCO Annual Meeting, NY, USA: American Society of Clinical Oncology.

Joshua, A., Nordman, I., Venkataswaran, R., Clarke, S., Stockler, M., Boyer, M. (2005). Weekly docetaxel as second line treatment after mitozantrone for androgen-independent prostate cancer. Internal Medicine Journal, 35(8), 468-472. [More Information]

Baker, S., Van Schaik, R., Rivory, L., Ten Tije, A., Dinh, K., Graveland, W., Schenk, P., Charles, J., Clarke, S., Carducci, M., Sparreboom, A., et al (2004). Factors Affecting Cytochrome P-450 3A Activity In Cancer Patients. Clinical Cancer Research, 10(12), 8341-8350. [More Information]

Tobin, P., Rivory, L., Clarke, S. (2004). Inhibition of acetylcholinesterase in patients receiving irinotecan (camptothecin-11). Pharmacology and Therapeutics, 76(5), 505-506. [More Information]

Vardy, J., Engelhardt, K., Cox, K., Jacquet, J., McDade, A., Boyer, M., Beale, P., Clarke, S., Stockler, M., Loneragan, R., Waugh, R., Clarke, S. (2004). Long-Term Outcome Of Radiological-Guided Insertion Of Implanted Central Venous Access Port Devices (Cvapd) For The Delivery Of Chemotherapy In Cancer Patients: Institutional Experience And Review Of The Literature. British Journal of Cancer, 91(6), 1045-1049. [More Information]

Blair, E., Rivory, L., Clarke, S., McLachlan, A. (2004). Population Pharmacokinetics Of Raltitrexed In Patients With Advanced Solid Tumours. British Journal of Clinical Pharmacology, 57(4), 416-426. [More Information]

Charles (nee Slaviero), K., Clarke, S., McLachlan, A., Blair, E., Rivory, L. (2004). Population Pharmacokinetics Of Weekly Docetaxel In Patients With Advanced Cancer. British Journal of Clinical Pharmacology, 57(1), 44-53. [More Information]

Zhang, M., Boyer, M., Rivory, L., Hong, A., Clarke, S., Stevens, G., Fife, K. (2004). Radiosensitization Of Vinorelbine And Gemcitabine In Nci-H460 Non-Small-Cell Lung Cancer Cells. International Journal of Radiation: Oncology – Biology – Physics, 58(2), 353-360. [More Information]

Featherstone, C., Clarke, S., Jackson, M., Shannon, K., McNeil, E., Tin, M., Clifford, A., O’Brien, C. (2004). Treatment Of Advanced Cancer Of The Larynx And Hypopharynx With Chemoradiation. ANZ Journal of Surgery, 74(7), 554-558. [More Information]

Smit, E., Mattson, K., von Pawel, J., Manegold, C., Clarke, S., Postmus, P. (2003). ALIMTA® (pemetrexed disodium) as second-line treatment of non-small-cell lung cancer: a phase II study. Annals of Oncology, 14(3), 455-460. [More Information]

Clarke, S. (2003). An 85-year old woman with metastatic liver disease: clinical case review. Medicine Today, 4(1), 72-73.

Charles (nee Slaviero), K., Read, J., Clarke, S., Rivory, L. (2003). Baseline Nutritional Assessment in Advanced Cancer Patients Receiving Palliative Chemotherapy. Nutrition and Cancer: an international journal, 46(2), 148-157.

Tattersall, M., Clarke, S. (2003). Developments in drug delivery: implications for cancer care. Current Opinion in Oncology, 15(4), 293-299. [More Information]

Van Der Wall, H., Clarke, S., Murray, I. (2003). Evaluation of primary bone tumours. In Peter J. Ell & Sanjiv Sam Gambhir (Eds.), Nuclear Medicine in Clinical Diagnosis and Treatment. 3rd ed, (pp. 623-639). Edinburgh: Churchill Livingstone.

Charles (nee Slaviero), K., Clarke, S., Rivory, L. (2003). Inflammatory response: an unrecognised source of variability in the pharmacokinetics and pharmacodynamics of cancer chemotherapy. The Lancet Oncology, 4(4), 224-232. [More Information]

Saw, R., Morgan, M., Koorey, D., Painter, D., Findlay, M., Stevens, G., Clarke, S., Chapuis, P., Solomon, M. (2003). P53, deleted in colorectal cancer gene, and thymidylate synthase as predictors of histopathologic response and survival in low, locally advanced rectal cancer treated with preoperative adjuvant therapy. Diseases of the Colon and Rectum, 46(2), 192-202. [More Information]

Li, K., Clarke, S., Rivory, L. (2003). Quantitation of plasma thymidine by high-performance liquid chromatography – atmospheric pressure chemical ionization mass spectromentry and its application to pharmocodynamic studies in cancer patients. Analytica Chimica Acta, 486(1), 51-61. [More Information]

Van Der Wall, H., Clarke, S., Murray, I. (2003). The evaluation of malignancy: metastatic bone disease. In Peter J. Ell & Sanjiv Sam Gambhir (Eds.), Nuclear Medicine in Clinical Diagnosis and Treatment. 3rd ed, (pp. 641-655). Edinburgh: Churchill Livingstone.

Tobin, P., Dodds, H., Clarke, S., Schnitzler, M., Rivory, L. (2003). The relative contributions of carboxylesterase and beta-glucuronidase in the formation of SN-38 in human colorectal tumours. Oncology Reports, 10(6), 1977-1979.

Aristides, M., Chen, J., Schulz, M., Williamson, E., Clarke, S., Grant, K. (2002). Conjoint analysis of a new chemotherapy: willingness to pay and preference for the features of raltitrexed versus standard therapy in advanced colorectal cancer. PharmacoEconomics, 20(11), 775-784. [More Information]

Cunningham, D., Zalcberg, J., Maroun, J., James, R., Clarke, S., Maughan, T., Vincent, M., Schulz, J., Gonzalez Baron, M., Facchini, T. (2002). Efficacy, tolerability and management of raltitrexed (Tomudex TM) monotherapy in patients with advanced colorectal cancer: a review of phase II/III trials. European Journal of Cancer, 38(4), 478-486. [More Information]

Rivory, L., Charles (nee Slaviero), K., Clarke, S. (2002). Hepatic cytochrome P450 3A drug metabolism is reduced in cancer patients who have an acute-phase response. British Journal of Cancer, 87(3), 277-280. [More Information]

Vardy, J., Wong, E., Izard, M., Clifford, A., Clarke, S. (2002). Life-threatening anaphylactoid reaction to amifostine used with concurrent chemoradiotherapy for nasopharyngeal cancer in a patient with dermatomyositis: a case report with literature review. Anti-Cancer Drugs, 13(3), 327-330. [More Information]

Clarke, S. (2002). New treatments for advanced and metastatic colorectal cancer – clinical applications. Australian Prescriber, 25(5), 111-113.

Rischin, D., Ackland, S., Smith, J., Garg, M., Clarke, S., Millward, M., Toner, G., Zalcberg, J. (2002). Phase I and pharmacokinetic study of docetaxel in combination with epirubicin and cyclophosphamide in advanced cancer: dose escalation possible with granulocyte colony-stimulating factor, but not with prophylactic antibodies. Annals of Oncology, 13(11), 1810-1818. [More Information]

Clarke, S., Abratt, R., Goedhals, L., Boyer, M., Millward, M., Ackland, S. (2002). Phase II trial of pemetrexed disodium (ALIMTA[R], LY231514) in chemotherapy-naive patients with advanced non-small-cell lung cancer. Annals of Oncology, 13(5), 737-741. [More Information]

Rivory, L., Clarke, S., Boyer, M., Bishop, J. (2001). Highly sensitive analysis of the antifolate pemetrexed sodium, a new cancer agent, in human plasma and urine by high-performance liquid chromatography. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences, 765, 135-140.

Rivory, L., Charles (nee Slaviero), K., Hoskins, J., Clarke, S. (2001). The erythromycin breath test for the prediction of drug clearance. Clinical Pharmacokinetics, 40, 151-158.

Clarke, S., Bishop, J., Dodds, H., Rivory, L., Ong,, S. (2001). Toxicity of irinotecan (CPT-11) and hepato-renal dysfunction. Anti-Cancer Drugs, 12, 619-625. [More Information]

Clarke, S., Beale, P., Rivory, L. (2000). Clinical and preclinical pharmacokinetics of raltitrexed. Clinical Pharmacokinetics, 39, 429-443.

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