Deborah was awarded her PhD in 1996 and then completed three years postdoctoral study at the Dane Farber Cancer Institute, Harvard Medical School Boston USA. Here she contributed in the discovery and characterisation of PTEN, ‘the most highly mutated tumour suppressor in the post p53 era, with 2 papers on this work published in Nature Genetics that remain pivotal in the field.

Professor Marsh was head of the Functional Genomics Laboratory at The Kolling Institute of Medical Research for over twenty years and has recently, in 2018, taken on a new position at The University of Technology, Sydney.

 

Research Interests

Professor Marsh has particular interest in the molecular nature of endocrine tumorigenesis. Her research involved in the development of certain cancers aims to identify new markers with value in cancer diagnostics and improved therapeutics, as well as gain insights into the normal function of healthy cells.

“Targeting the “guardian of the genome” for the treatment of ovarian cancer”

Ramsay Research and Teaching Fund 2015

“Investigating the complexity of p53 pathways in ovarian cancer: are non-coding RNAs the key?”

Sydney Vital 2015

“Targeting chemoresistant cancer stem cells for the treatment of ovarian cancer”

Sydney Vital 2015

“INOVATe – Individualised Ovarian Cancer Treatment Through Integration of Genomic Pathology into Multidisciplinary Care”

Cancer Institute NSW 2015

“Informing policy and practice standards (consent and data linkage) for NSW cancer biobanks: An in-depth analysis of community attitudes towards biobanks among NSW residents”

CINSW Biobanking Stakeholder Network 2015

“Streamlining specimen preparation for researchers from samples stored in biobanks”

CINSW 2015

“Live cell imager for enhancement of pre-clinical cancer studies in the Hunter Translational Cancer Research Centre”

CINSW 2015

“Monoubiquitinated histone H2B – marking key pathways in ovarian cancer”

Cancer Council NSW 2013

“H2Bub1 – a new cancer biomarker: Investigating the potential of the epigenomic mark H2Bub1 for prostate cancer diagnostics and prognostics”

Ramsay Health Care 2015

Senior Research Fellowship A, “Molecular mechanisms and functional consequences – understanding endocrine tumorigenesis”

NHMRC 2011

Northern Translational Cancer Research Centre (NTCRC)

CINSW 2014

“Embedding patient tissue banking consent into routine clinical practice: To maximise state-wide consent and enable a patient-led approach to tissue banking”

CINSW Biobanking Stakeholder Network 2014

“Essential clinical annotation for NSW biobanks through data integration using State and Commonwealth datasets”

CINSW Biobanking Stakeholder Network 2014

“Improving biospecimen quality within BSN Biobanks”

CINSW Biobanking Stakeholder Network 2014

“Maximising support for breast cancer research by the Australian Breast Cancer Tissue Bank”

NBCF Infrastructure Grant 2012

Equipment Grants

Qseq Automated Personal DNA Sequencer

University of Sydney 2014

Marsh, D., Howell, V. (2010). The Use of Denaturing High Performance Liquid Chromatography (DHPLC) for Mutation Scanning of Hereditary Cancer Genes. In Michelle Webb (Eds.), Cancer Susceptibility: Methods and Protocols, (pp. 133-145). United States: Humana Press. [More Information]

Marsh, D., Zori, R. (2008). Cowden Syndrome. In Manfred Schwab (Eds.), Encyclopedia of Cancer, Vol. 1. Germany: Springer.

Marsh, D., Zori, R. (2005). Cowden Syndrome. In Fuchs J and Podda M (Eds.), Encyclopaedia of Diagnostics Genomics and Proteomics, (pp. 301-304). New York, USA: Marcel Dekker.

Marsh, D., Benn, D. (2005). Von Hippel-Lindau Disease. In Fuchs J and Podda M (Eds.), Encyclopaedia of Diagnostics Genomics and Proteomics, (pp. 1329-1333). New York, USA: Marcel Dekker.

Marsh, D., Zori, R. (2001). Cowden Syndrome. In Schwab M (Eds.), Encyclopedic Reference of Cancer, (pp. 222-226). United States: Springer.

Marsh, D., Stratakis, C. (2001). Hamartoma Syndromes: Harmatoma and Lentiginosis Syndromes: Clinical and Molecular Aspects. In Patricia L.M. Dahlia, Charis Eng and Grossman AB (Eds.), Genetic Disorders of Endocrine Neoplasia, Vol. 28, (pp. 167-213). Switzerland: S. Karger AG.

Shah, J., Gard, G., Yang, J., Maidens, J., Valmadre, S., Soon, P., Marsh, D. (2018). Combining serum microRNA and CA-125 as prognostic indicators of preoperative surgical outcome in women with high-grade serous ovarian cancer. Gynecologic Oncology, 148(1), 181-188. [More Information]

Cole, A., Zhu, Y., Dwight, T., Yu, B., Dickson, K., Gard, G., Maidens, J., Valmadre, S., Gill, A., Clifton-Bligh, R., Marsh, D. (2017). Comprehensive analyses of somatic TP53 mutation in tumors with variable mutant allele frequency. Scientific Data, 4, 1-8. [More Information]

Cole, A., Dwight, T., Gill, A., Dickson, K., Zhu, Y., Clarkson, A., Gard, G., Maidens, J., Valmadre, S., Clifton-Bligh, R., Marsh, D. (2016). Assessing mutant p53 in primary high-grade serous ovarian cancer using immunohistochemistry and massively parallel sequencing. Scientific Reports, 6, 1-12. [More Information]

Shah, J., Soon, P., Marsh, D. (2016). Comparison of Methodologies to Detect Low Levels of Hemolysis in Serum for Accurate Assessment of Serum microRNAs. PloS One, 11(4), 1-12. [More Information]

Wheate, N., Dickson, K., Kim, R., Nematollahi, A., Macquart, R., Kayser, V., Yu, G., Church, W., Marsh, D. (2016). Host-Guest Complexes of Carboxylated Pillar[n]arenes With Drugs. Journal of Pharmaceutical Sciences, 105(12), 3615-3625. [More Information]

Marsh, D., Eng, C. (2016). Lessons learnt from outstanding mid-career women in endocrine cancer research. Endocrine-Related Cancer, 23(11), E5-E7. [More Information]

Dickson, K., Cole, A., Gill, A., Clarkson, A., Gard, G., Chou, A., Kennedy, C., Henderson, B., Fereday, S., Traficante, N., deFazio, A., Clifton-Bligh, R., Marsh, D., et al (2016). The RING finger domain E3 ubiquitin ligases BRCA1 and the RNF20/RNF40 complex in global loss of the chromatin mark histone H2B monoubiquitination (H2Bub1) in cell line models and primary high-grade serous ovarian cancer. Human Molecular Genetics, 25(24), 5460-5471. [More Information]

Chung, L., Phillips, L., Lin, Z., Moore, K., Marsh, D., Boyle, F., Baxter, R. (2015). A novel truncated form of S100P predicts disease-free survival in patients with lymph node positive breast cancer. Cancer Letters, 368(1), 64-70. [More Information]

Kan, C., Howell, V., Hahn, M., Marsh, D. (2015). Genomic Alterations as Mediators of miRNA Dysregulation in Ovarian Cancer. Genes Chromosomes and Cancer, 54(1), 1-19. [More Information]

Cole, A., Clifton-Bligh, R., Marsh, D. (2015). Histone H2B monoubiquitination – roles to play in human malignancy. Endocrine-Related Cancer, 22(1), T19-T33. [More Information]

Marsh, D., Foster, K., Scott, C. (2015). Match that PhD. Nature, 523, 247-247. [More Information]

Marsh, D. (2015). Networks regulating ubiquitin and ubiquitin-like proteins promise new therapeutic targets. Endocrine-Related Cancer, 22(1), E1-E3. [More Information]

Pillai, U., Phillips, K., Wilkins, G., Baxter, R., Benn, D., Parker, N., Smith, R., Marsh, D. (2014). Factors that may influence the willingness of cancer patients to consent for biobanking. Biopreservation and Biobanking, 12(6), 409-414. [More Information]

Marsh, D., Shah, J., Cole, A. (2014). Histones and their modifications in ovarian cancer – drivers of disease and therapeutic targets. Frontiers in Oncology, 4, 1-12. [More Information]

Chung, L., Katrina, M., Phillips, L., Boyle, F., Marsh, D., Baxter, R. (2014). Novel serum protein biomarker panel revealed by mass spectrometry and its prognostic value in breast cancer. Breast Cancer Research, 16(3), 1-12. [More Information]

Garcia-Closas, M., Couch, F., Lindstrom, S., Michailidou, K., Schmidt, M., Brook, M., Orr, N., Rhie, S., Riboli, E., Feigelson, H., Carpenter, J., Balleine, R., et al (2013). Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nature Genetics, 45(4), 392-398. [More Information]

Chung, L., Shibli, S., Moore, K., Elder, E., Boyle, F., Marsh, D., Baxter, R. (2013). Tissue biomarkers of breast cancer and their association with conventional pathologic features. British Journal of Cancer, 108(2), 351-360. [More Information]

Kan, C., Hahn, M., Gard, G., Maidens, J., Huh, J., Marsh, D., Howell, V. (2012). Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer. BMC Cancer, 12, 1-9. [More Information]

Mertens, I., Baxter, R., Marsh, D. (2012). Gonadotropin signalling in epithelial ovarian cancer. Cancer Letters, 324(2), 152-159. [More Information]

Paul, R., Elston, M., Gill, A., Marsh, D., Beer, I., Wolmarans, L., Conaglen, J., Meyer-Rochow, G. (2012). Hypercalcaemia due to parathyroid carcinoma presenting in the third trimester of pregnancy. Australian and New Zealand Journal of Obstetrics and Gynaecology, 52(2), 204-207. [More Information]

Gribben, L., Baxter, R., Marsh, D. (2012). Insulin-like growth factor binding protein-3 inhibits migration of endometrial cancer cells. Cancer Letters, 317(1), 41-48. [More Information]

Hahn, M., Dickson, K., Jackson, S., Clarkson, A., Gill, A., Marsh, D. (2012). The tumor suppressor CDC73 interacts with the ring finger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B monoubiquitination. Human Molecular Genetics, 21(3), 559-568. [More Information]

Lin, W., Martin, J., Marsh, D., Jack, M., Baxter, R. (2011). Involvement of insulin-like growth factor binding protein-3 in the effects of the histone deacetylase inhibitor MS-275 in hepatoma cells. Journal of Biological Chemistry, 286(34), 29540-29547. [More Information]

Lim, S., Elston, M., Gill, A., Marsh, D., Conaglen, J. (2011). Metastatic parathyroid carcinoma initially misdiagnosed as parathyroid adenoma: The role of parafibromin in increasing diagnostic accuracy. Internal Medicine Journal, 41(9), 695-699. [More Information]

Marsh, D., Gimm, O. (2011). Multiple endocrine neoplasia: types 1 and 2. Advances in Oto-Rhino-Laryngology, 70(-), 84-90. [More Information]

Marsh, D., Trahair, T., Kirk, E. (2011). Mutant AKT1 in Proteus syndrome. New England Journal of Medicine, 365(22), 2141-2142. [More Information]

Hahn, M., Howell, V., Gill, A., Clarkson, A., Weaire-Buchanan, G., Robinson, B., Delbridge, L., Gimm, O., Schmitt, W., Teh, B., Marsh, D. (2010). CDC73/HRPT2 CpG island hypermethylation and mutation of 5′-untranslated sequence are uncommon mechanisms of silencing parafibromin in parathyroid tumors. Endocrine-Related Cancer, 17(1), 273-282. [More Information]

Mertens, I., Bolitho (nee Donald), C., Baxter, R., Marsh, D. (2010). Gonadotropin-induced ovarian cancer cell migration and proliferation require extracellular signal-regulated kinase 1/2 activation regulated by calcium and protein kinase C{delta}. Endocrine-Related Cancer, 17(2), 335-349. [More Information]

Bolitho (nee Donald), C., Hahn, M., Baxter, R., Marsh, D. (2010). The chemokine CXCL1 induces proliferation in epithelial ovarian cancer cells by transactivation of the epidermal growth factor receptor. Endocrine-Related Cancer, 17(4), 929-940. [More Information]

Howell, V., Gill, A., Clarkson, A., Nelson, A., Dunne, R., Delbridge, L., Robinson, B., Teh, B., Gimm, O., Marsh, D. (2009). Accuracy of Combined Protein Gene Product 9.5 and Parafibromin Markers for Immunohistochemical Diagnosis of Parathyroid Carcinoma. The Journal of Clinical Endocrinology and Metabolism, 94(2), 434-441. [More Information]

Meyer-Rochow, G., Smith, J., Richardson, A., Marsh, D., Sidhu, S., Robinson, B., Benn, D. (2009). Denaturing High Performance Liquid Chromatography Detection of SDHB, SDHD, and VHL Germline Mutations in Pheochromocytoma. Journal of Surgical Research, 157, 55-62. [More Information]

Hahn, M., McDonnell, J., Marsh, D. (2009). The effect of disease-associated HRPT2 mutations on splicing. Journal of Endocrinology, 201(3), 387-396. [More Information]

Marsh, D., Trahair, T., Martin, J., Chee, W., Walker, J., Kirk, E., Baxter, R., Marshall, G. (2008). Rapamycin treatment for a child with germline PTEN mutation. Nature Clinical Practice Oncology, 5(6), 357-361. [More Information]

Marsh, D., Hahn, M., Howell, V., Gill, A. (2007). Molecular diagnosis of primary hyperparathyroidism in familial cancer syndromes. Expert Opinion on Medical Diagnostics, 1(3), 377-392. [More Information]

Hahn, M., Marsh, D. (2007). Nucleolar localization of parafibromin is mediated by three nucleolar localization signals. FEBS Letters, 581(26), 5070-5074. [More Information]

Benn, D., Marsh, D., Robinson, B., Riches, J. (2006). Genetic testing in pheochromocytoma- and paraganglioma-associated syndromes. Annals of the New York Academy of Sciences, 1073, 104-111. [More Information]

Gill, A., Clarkson, A., Gimm, O., Keil, J., Dralle, H., Howell, V., Marsh, D. (2006). Loss of Nuclear Expression of Parafibromin Distinguishes Parathyroid Carcinomas and Hyperparathyroidism-Jaw Tumor (HPT-JT) Syndrome-related Adenomas From Sporadic Parathyroid Adenomas and Hyperplasias. American Journal of Surgical Pathology, 30(9), 1140-1149. [More Information]

Gimm, O., Lorenz, K., Nguyen Thanh, P., Schneyer, U., Bloching, M., Howell, V., Marsh, D., Teh, B., Krause, U., Dralle, H. (2006). Prophylactic parathyroidectomy for familial parathyroid carcinoma. Chirurg, 77(1), 15-24. [More Information]

Marsh, D., Baxter, R., Moscova, M. (2006). Protein chip discovery of secreted proteins regulated by the phosphatidylinositol 3-kinase pathway in ovarian cancer cell lines. Cancer Research, 66(3), 1376-1383. [More Information]

Howell, V., Cardinal, J., Richardson, A., Gimm, O., Robinson, B., Marsh, D. (2006). Rapid Mutation Screening for HRPT2 and MEN1 Mutations Associated with Familial and Sporadic Primary Hyperparathyroidism. Journal of molecular diagnostics, 8(5), 559-566. [More Information]

Dahia, P., Ross, K., Wright, M., Hayashida, C., Santagata, S., Barontini, M., Kung, A., Sanso, G., Powers, J., Benn, D., Marsh, D., Robinson, B., et al (2005). A HIF1-alpha Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas. PLoS Genetics, 1(1), 72-80. [More Information]

Benn, D., Gimenez-Roqueplo, A., Reilly, J., Bertherat, J., Burgess, J., Byth Wilson, K., Croxson, M., Dahia, P., Elston, M., Gimm, O., Marsh, D., Robinson, B., et al (2005). Clinical presentation and penetrance of Pheochromocytoma/ Paraganglioma syndromes. The Journal of Clinical Endocrinology and Metabolism, 91(3), 827-836. [More Information]

Hahn, M., Marsh, D. (2005). Identification of a functional bipartite nuclear localization signal in the tumor suppressor parafibromin. Oncogene, 24(41), 6241-6248. [More Information]

Howell, V., Zori, R., Stalker, H., Williams, C., Jesse, N., Nelson, A., Robinson, B., Marsh, D. (2004). A molecular diagnosis of hyperparathyroidism-Jaw tumor syndrome in an adolescent with recurrent kidney stones. The Journal of Pediatrics, 145(4), 567-567. [More Information]

Kirk, E., Smith, J., Field, M., Marshall, G., Marsh, D. (2004). Diagnosis of Proteus Syndrome was correct. American Journal of Medical Genetics, Part A, 130A (2), 214-215. [More Information]

Haven, C., Howell, V., Eilers, P., Dunne, R., Takahashi, M., Van Puijenbroek, M., Furge, K., Kievit, J., Tan, M., Fleuren, G., Robinson, B., Delbridge, L., Philips, J., Nelson, A., Marsh, D., et al (2004). Gene Expression Of Parathyroid Tumors: Molecular Subclassification And Identification Of The Potential Malignant Phenotype. Cancer Research, 64(20), 7405-7411. [More Information]

Marsh, D., Morreau, H., Teh, B. (2004). HRPT2 and parathyroid cancer. The Lancet Oncology, 5(2), 78-78. [More Information]

McDonnell, C., Benn, D., Marsh, D., Robinson, B., Zacharin, M. (2004). K40E: A Novel Succinate Dehydrogenase (Sdh)B Mutation Causing Familial Phaeochromocytoma And Paraganglioma. Clinical Endocrinology, 61(4), 510-514. [More Information]

Marsh, D. (2003). “Endocrine Tumors” – book review. Cancer Forum, 11, 1810-181.

Bernard, M., Sidhu, S., Berger, N., Peix, J., Marsh, D., Robinson, B., Gaston, V., Le Bouc, Y., Gicquel, C. (2003). A case report in favor of a multistep adrenocortical tumorigenesis. The Journal of Clinical Endocrinology and Metabolism, 88(3), 998-1001. [More Information]

Marsh, D., Gimm, O. (2003). Does a somatic deletion in RET clarify the sporadic nature of medullary thryoid carcinoma? Journal Of Endocrinological Investigation, 11, 381-383.

Marsh, D., Theodosopoulos, G., Martin-Schulte, K., Richardson, A., Philips, J., Roher, H., Delbridge, L., Robinson, B. (2003). Genome-wide copy number imbalances identified in familial and sproadic medullary thyroid carcinoma. The Journal of Clinical Endocrinology and Metabolism, 88(4), 1866-1872. [More Information]

Zhou, X., Marsh, D., Morrison, C., Chaudhury, A., Maxwell, M., Reifenberger, G., Eng, C. (2003). Germline inactivation of PTEN and dysregulation of the phosphoinositol-3-kinase/Akt pathway cause human Lhermitte-Duclos disease in adults. American Journal of Human Genetics, 73(5), 1191-1198. [More Information]

Howell, V., Haven, C., Kahnoski, K., Khoo, S., Petillo, D., Chen, J., Fleuren, G., Robinson, B., Delbridge, L., Philips, J., Marsh, D., et al (2003). HRPT2 mutations are associated with malignancy in sporadic parathyroid tumours. Journal of Medical Genetics, 40(9), 657-663.

Benn, D., Croxson, M., Tucker, K., Bambach, C., Richardson, A., Delbridge, L., Pullan, P., Hammond, J., Marsh, D., Robinson, B. (2003). Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporatid phaeochromaocytomas. Oncogene, 22(9), 1358-1364. [More Information]

Sidhu, S., Marsh, D., Theodosopoulos, G., Philips, J., Bambach, C., Campbell, P., Magarey, C., Russell, C., Martin-Schulte, K., Roher, H., Delbridge, L., Robinson, B. (2002). Comparative genomic hybridization analysis of adrenocortical tumors. The Journal of Clinical Endocrinology and Metabolism, 87(7), 3467-3474. [More Information]

Dwight, T., Philips, J., Robinson, B., Twigg, S., Kytola, S., Delbridge, L., Teh, B., Marsh, D., Theodosopoulos, G., Nelson, A., et al (2002). Genetic analysis of lithium-associated parathyroid tumors. European Journal of Endocrinology, 146(5), 619-627.

Marsh, D., Zori, R. (2002). Genetic insights into familial cancers – update and recent discoveries. Cancer Letters, 181(2), 125-164. [More Information]

Benn, D., Marsh, D., Robinson, B. (2002). Genetics of pheochromocytoma and paraganglioma. Current Opinion in Endocrinology, Diabetes and Obesity, 9(1), 79-86.

Smith, J., Kirk, E., Theodosopoulos, G., Marshall, G., Walker, J., Rogers, M., Field, M., Brereton, J., Marsh, D. (2002). Germline mutation of the tumour suppressor PTEN in Proteus syndrome. Journal of Medical Genetics, 39, 937-940.

Dwight, T., Nelson, A., Theodosopoulos, G., Richardson, A., Learoyd, D., Philips, J., Delbridge, L., Zedenius, J., Teh, B., Larsson, C., Marsh, D., Robinson, B. (2002). Independent Genetic Events Associated with the Development of Multiple Parathyroid Tumors in Patients with Primary Hyperparqathyroidism. American Journal of Pathology, 161(4), 1299-1306.

Nelson, A., Robinson, B., Marsh, D., Dwight, T., Teh, B., Larsson, C. (2002). Parathyroid tumorigenesis in association with primary hyperparathyroidism. Current Opinion in Endocrinology, Diabetes and Obesity, , 51-60.

Andrew, S., Capes-Davis, A., Delhanty, P., Marsh, D., Mulligan, L., Robinson, B. (2002). Transcriptional repression of the RET proto-oncogene by a mitogen activated protein kinase-dependent signalling pathway. Gene, 298(1), 9-19. [More Information]

Marsh, D., Robinson, B., Fackenthal, J., Riches, J., Cummings, S., Eng,, C., Olopade, O. (2001). Male breast cancer in Cowden syndrome patients with germline PTEN mutations. Journal of Medical Genetics, 38, 159-164.

Nelson, A., Robinson, B., Mason, R., Marsh, D., Holm,, I., Cowell, C., Carpenter, T. (2001). Mutational analysis and genotype-phenotype correlation of the PHEX gene in X-Linked hypophosphphatiemic rickets. The Journal of Clinical Endocrinology and Metabolism, 86(8), 3889-3899. [More Information]

Marsh, D., Howell, V., Benn, D., Robinson, B., Theodosopoulos, G., Riches, J., Proos, A., Eng,, C. (2001). Rapid mutation scanning of genes associated with familial cancer syndromes using denaturing high-performance liquid chromatography. Neoplasia (Spanish Edition): oncologia multidisciplinaria, 3, 236-244.

Moscova, M., Marsh, D., Baxter, R. (2005). Identification of Cytokines regulated by phosphatidylinositol-3 kinase in ovarian cancer. AACR-NCI-EORTC International Conference 2005, United States: American Association for Cancer Research.

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