Publications in 2018-2019 with partial support of SV

  1. Clement, W. Chen, W. Deng and E. M. Goldys. ‘X-ray radiation-induced and targeted photodynamic therapy with folic acid-conjugated biodegradable nanoconstructs’ International Journal of Nanomedicine, 2018 (vol 13, page No:3553-3570) , DOI: https://doi.org/10.2147/IJN.S164967, QI: 7/121, 94%, 4.80
  2. Deng, W. Chen, S. Clement, A. Guller, Z. Zhao, Z., A. Engel and E. M. Goldys, (2018). ‘Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation’, Nature Communications, 9(1), 2713, QI:1/187, 98%, 12.41
  3. Guller, A. Nadort, A. N. Generalova, E. V. Khaydukov, A.V. Nechaev, I.A. Kornienko, E.V.Petersen, L.Liang, A.B. Shekhter, Y. Qian, E.M. Goldys, A.V. Zvyagin, ‘Rational Surface Design of Upconversion Nanoparticles with Polyethylenimine Coating for Biomedical Applications: Better Safe than Brighter?’ ACS Biomaterials Science & Engineering (2018): 4 (9), pp 3143–3153. DOI: 10.1021/acsbiomaterials.8b00633, QI: 29/19, 85%, 4.37
  4. “Computer-assisted cystoscopy diagnosis of bladder cancer” , Gosnell, M. E., Polikarpov, D. M., Goldys, E. M., Zvyagin, A. V., Gillatt, D. A., Urologic Oncology-Seminars and Original Investigations, 36(1). (2018), doi:10.1016/j.urolonc.2017.08.026, QI: 12/97, 88%, 2.41

 

Conference papers 2018-2019 with partial support of SV

  1. Z. Kautzka,S. Clement,  Goldys, W. Deng, ‘Light-triggered liposomal cargo delivery platform incorporating photosensitizers and gold nanoparticles for enhanced singlet oxygen generation and increased cytotoxicity’, Proc. SPIE 10476, 104760A, doi: 10.1117/12.2286552 (SPIE BiOS, San Francisco, California, United States, 27, Jan-01, Feb, 2018)
  2. “Biodegradable nanoconstructs for targeted deep tumour therapy”, Clement, W. Chen, W. Deng, E. Goldys, 27 Jan – 1 Feb 2018, SPIE BIOS, San Francisco USA. (oral)
  3. “Light-triggered liposomal cargo delivery platform incorporating photosensitizers and gold nanoparticles for enhanced singlet oxygen generation and increased cytotoxicity” Kautzka, S. Clement, E. Goldys and W Deng, SPIE BiOS, 27 Jan – 1 Feb 2018, San Francisco, California USA. (oral)
  4. “Cellular photodynamic therapy by PLGA incorporating photosensitizers in combination with X-ray radiation” S. Clement W. Chen, W. Deng, E. Goldys, International Conference on Nanoscience and Nanotechnology (ICONN 2018), 29 Jan – 2 Feb 2018, Wollongong, NSW, Australia. (poster presentation)
  5. “Organ-specific microenvironments change the effects of nanomaterials and nanoformulated drugs”, A. Guller, Z. Khabir, A. Nadort, I. Kuschnerus, L. Liang, A. Garcia-Bennett, Y. Qian, E. Goldys and A. Zvyagin, International Conference on Nanoscience and Nanotechnology (ICONN 2018), 29 Jan – 2 Feb 2018, Wollongong, Australia.
  6. “Developing three-dimensional brain tumours as a platform for quantitative fluorescence imaging”, A. Nadort, Anna Guller, Z. Khabir, A. Zvyagin, Y. Qian, A. Davidson and E. Goldys, International Conference on Nanoscience and Nanotechnology (ICONN 2018), 29 Jan – 2 Feb 2018, Wollongong, Australia.
  7. “Stable and photoresponsive liposome-polycation-DNA (LPD) nanocomplexes for enhanced gene delivery in cancer cells via endolysosomal escape”, W. Chen, W. Deng, X. Xu, J. Nhu Vo and E. Goldys, ASBTE Conference 2018, 3-5 Apr 2018, Perth, Australia. (oral)
  8. “Nanomaterials and nanoformulated drugs behave differently in conventional monolayer cell cultures and in 3D engineered tissues in vitro”, A. Guller, Z. Khabir, I. Kuschnerus, A. Nadort, L. Liang, A. Garcia-Bennett, Y. Qian, A. Zvyagin and E. Goldys, 9th International Nanomedicine Conference 2018, 25-27 Jun 2018, Sydney, Australia.
  9. “Light-triggered liposomes for enhanced gene/drug delivery in cancer treatment”, W. Chen, W. Deng and E. Goldys, 14th Australia-China Symposium, 26-29 Aug 2018, Changchun, China. (invited presentation)
  10. “Closer to nature in vitro: organ-specific extracellular matrix-based three dimensional models of cancer”, A. Nadort, S. Iqbal, N. Packer, E. Goldys and A. Guller, The ComBio-2018, 23-26 Sep 2018, Sydney, Australia (invited)
  11. “Controlled drug release from a liposomal delivery platform triggered by X-ray radiation”, Deng, W. Chen, S. Clement, A. Guller, Z. Zhao, A. Engel and E. Goldys, Sydney Cancer Conference 2018, 11-12 Oct 2018, Sydney, Australia. (oral).
  12. “Liver extracellular matrix modulates growth, invasion and drug sensitivity of metastatic breast carcinoma”, A. Guller, V. Rozova, A. Nadort, Z. Khabir, I. Kuschnerus, A. Garcia-Bennett, L. Liang, Y. Qian, E. Goldys and A. Zvyagin, The Sydney Cancer Conference, 11-12 Oct 2018, Sydney, Australia.
  13. “Controlled gene and drug release from a liposomal delivery platform triggered by light (or X-ray radiation)”, Deng, W. Chen, S. Clement, A. Guller, Z. Zhao, A. Engel and E. Goldys, The 3rd International Conference on Emerging Advanced Nanomaterials, (ICEAN 2018), 30 Oct– 2 Nov 2018, Newcastle Exhibition and Convention Center, Newcastle, Australia. (oral)
  14. “Tissue Engineering Models of Breast Carcinoma and Malignant Glioma for Cancer Biology research, Drug Testing and Diagnostic Tools’ Development. 2018 TERMIS (Tissue Engineering and Regenerative Medicine International Society)”, A. Guller, A. Nadort, Z. Khabir, I. Kuschnerus, S. Iqbal, V. Rozova, L. Liang, L. Parker, A. Garcia-Bennett, N. Packer, E. Goldys, A. Zvyagin and Y. Qian, The 5th World Congress 2018, 4-7 Sep 2018, Kyoto, Japan.
  15. “Nanoparticles beyond a Petri dish: a reality check for biomedical nanomaterials in 3D engineered tissues”, A. Guller, Kuschnerus, A. Nadort, Z. Khabir, V. Rozova, L. Liang, A. Garcia-Bennett, Y. Qian, A. Zvyagin, E. Goldys, In SPIE BiOS, SPIE Photonics West-2019, 1-6 February 2019, San Francisco, USA. Vol. (SPIE Paper Number 10891-34) – oral presentation
  16. “Engineering 3D living brain tumour equivalents as macroscopic test-systems for the development of optical imaging and sensing applications”, A. Nadort, M. Vaez Zadeh, S. Iqbal, M. Ghanimi Fard, D. Polikarpov, S. Sachdev, L. Parker, Q. Yi, A. Davidson, N. Packer, E. Goldys, A. Guller, SPIE BiOS (SPIE Photonics West-2019), SPIE, 1-6 February 2019, San Francisco, USA. (oral presentation)
  17. “Controlled drug release from a X-ray triggered liposomal delivery platform for colorectal cancer treatment” W. Deng, W. Chen, S. Clement, A. Guller, Z. Zhao, A. Engel, E. Goldys, SPIE BiOS (SPIE Photonics West-2019), SPIE, 1-6 February 2019, San Francisco, USA. (oral Presentation)
  18. “Nuclear targeted x-ray activated photodynamic therapy: a solution to treat pancreatic cancer” S. Clement, A. Anwer, W. Deng, B. C. Wilson, C. Allen, E.M. Goldys, SPIE BiOS (SPIE Photonics West-2019), SPIE, 1-6 February 2019, San Francisco, USA. -oral presentation
  19. “Combining ionising radiation with nanoconstructs: towards new options in cancer therapy” E.M. Goldys, S. Clement, W. Deng, SPIE BiOS (SPIE Photonics West-2019), SPIE, 1-6 February 2019, San Francisco, USA. (Conference Presentation) – Invited

 

Patents and innovation disclosures enabled by SV

  1. X-ray triggered liposome delivery strategy, Deng and E. Goldys, (PCT/AU2018/000247).
  2. CRISPR/Cas9-liposome delivery system, Deng, E. Goldys and Y. Aksoy, (Australian provisional patent No. 2019900286).

 

Projects supported by SV 2018-2019

  1. Guller, E. Goldys, W. Deng, Y. Sen, A. Zvyagin “Harnessing cancer-associated inflammation for the improvement of therapy of metastatic colorectal cancer (CRC): the experimental study on 3D tissue engineering models of CRC metastases to the liver,
  2. Guller E. Goldys, P. Sowman, A. Nadort, A. Zvyagin, Y. Sen, A. Davidson, ”Magnetic keys of a new toolbox for the treatment of brain cancer: a study on 3D engineered healthy and tumor brain organoids,
  3. Clement, “Fractionate radiation assisted, nuclear targeted therapeutical model for effective destruction of Pancreatic Cancer cells in vivo”

 

Grant applications made by SV researchers in my group in 2018-2019 – these were enabled by the data obtained with the support of SV

E.M. Goldys, A. Guller, W. Deng “Rapid combinatorial screening of novel drug combinations for effective brain cancer treatment”, CureBrainCancer Foundation, 2020-2021, $ 200,000

  1. Goldys, A. Guller, W. Deng, S. Clement. “Smart haemostatic wound dressings with on-demand responses for military trauma care”. HRPnet -Defence 2019, $ 155,362.
  2. Deng “New therapeutic option for lymph node metastasis in rectal cancer: radiation-triggered photodynamic therapy in deep tissue”, Career Development Fellowship 2019, Cancer Institute NSW, 2020-2022, $ 513,750
  3. Deng “Using nanocarriers for synergistic treatment towards colorectal cancer”, NHMRC Investigator grant 2020-2022, $ 1,630,565

W.Deng , Viive Howell and Alexander Engel “New therapeutic option for lymph node metastasis in rectal cancer: radiation-triggered photodynamic therapy in deep tissue” NHMRC Ideas grant 2020-2022, $ 261,790

W.Deng “New therapeutic option for lymph node metastasis in rectal cancer: radiation-triggered photodynamic therapy in deep tissue” , The Cancer Australia Priority-driven Cancer Research Scheme 2020-21, $ 135,800

W.Deng, “Nanostrategy for X-ray triggered chemotherapy towards rectal cancer treatment”Bridging grant 2019, The National Foundation for Medical Research and Innovation (NFMRI), 101,825

W.Deng, J.Campbell “Biomimetic materials for gene delivery and stem cell differentiation”, UNSW-CAS Bridging grant 2019 , $ 50,000

  1. Guller, “Two-faced bifunctional bioimplants (Janus wafers) for local adjuvant treatment of glioblastoma multiforme”, CureBrainCancer ECR Fellowship, 2020-2022, $ $343,724
  2. Deng UNSW-CAS Seed grant program (Bridging Grant), 2019, $ 50,000
  3. Deng National Foundation for Medical Research 2018 , $ 130,000

W.DengUsing biodegradable chemotherapy-free nanocarriers and low dose X-rays to treat rectal cancer”, Career Development Fellowship 2018, NHMRC (2019-2022)

W.Deng and Viive Howell “X-ray triggered photodynamic therapy for rectal cancer treatment” Mid-Career Research Grant 2018, Tour de Cure Foundation, $ 100 000

W.DengUsing biodegradable chemotherapy-free nanocarriers and low dose X-rays to treat rectal cancer”, New investigator project 2018, NHMRC (four years, about $400,000)

W.Deng,  Using biodegradable chemotherapy-free nanocarriers and low dose X-rays to treat rectal cancer”, Priority-driven young investigator project grant through NHMRC and Cure Cancer Australia (two years, $200,000)

  1. Deng, “Nanostrategy for a novel treatment towards rectal cancer”, Portfolio 2 National Foundation for Medical Research and Innovation grant 2018 (two years, $133,578)

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