Professor Mark Molloy has extensive knowledge and experience in proteomics and translational oncology biomarker research. In March 2018, Molloy was appointed inaugural Lawrence Penn Chair in Bowel Cancer Research at the Kolling Institute, Royal North Shore Hospital and University of Sydney. The creation of the chair is a $10.4 million initiative of Bowel Cancer Australia, the Bowel Cancer Research Foundation and The University of Sydney and is named after bowel cancer survivor Lawrence Penn.

Mark has worked at Macquarie University for 15 years, where he served as the Director of the Australian Proteome Analysis Facility (APAF) and interim Head of Chemistry and Biomolecular Sciences.

Mark completed his post-doctoral training in mass spectrometry in the laboratory of Professor Phillip Andrews at the University of Michigan Medical School. He then began a research scientist role in Pfizer Inc, using proteomics to discovery biomarkers of drug response and drug differentiation. He returned to Australia and undertook a prestigious NHMRC Biomedical career development award to apply proteomics to investigate prognostic and predictive biomarkers associated with colorectal cancer.

 

Research Interests

Mark’s expertise in the use of mass spectrometry as the core analytical technique supports collaborative research in many science and biomedical areas, where he has a strong focus on translational cancer research. Professor Molloy’s contribution in the application of proteomics work is evidenced by his grant success (career total $42.9M), publications (>150) and HDR student completions (13).

His areas of interest include the use of molecular profiling technologies for improved diagnosis, prognosis and identifying treatment response. He is focused on bowel cancer, but has also applied his skills to study melanoma, prostate cancer, thyroid cancer and lung cancer. He is also an expert in the use of mass spectrometry for analysis of plasma associated with clinical biomarker research. He collaborates with colleagues in fields of neurodegeneration and diabetes.

Other areas of interests include:

Biomarkers, cancers, protein phosphorylation, proteomics, translational research

National ACGs

FIELD NOvel Markers in Diabetes (NOMAD)

NHMRC 2018

Blood biomarkers for the diagnosis of pre-clinical Alzheimer’s disease employing the Dominantly Inherited Alzheimer Network cohort

NHMRC 2017

Developing insight into the molecular origins of familial and sporadic frontotemporal dementia and amyotrophic lateral sclerosis

NHMRC Boosting Dementia Research Initiative 2015

Cytometry by time of flight mass spectrometry platform for the Advanced Cytometry Facility

ACRF LIEF 2014

ARC Industrial Transformation Training Centre IC130100009 – A molecular technology platform for enabling the next revolution in the food industry

ARC Industrial Transformation Training Centre 2013

Developing new treatments for brain AVMs

NHMRC Project 2013

Characterising the beta-catenin nuclear targeting pathway in cancer

NHMRC Project 2013

ARC Discovery DP110104958 – Sugars in the real world: are cultured cancer cells a good model system for studying protein glycosylation?

ARC Discovery 2011

The role and regulation of protein methylation: a study using the recently developed methylation network of yeast

ARC Discovery 2011

Developing new treatments for brain vascular malformations.

Heart Foundation 2011

Better, faster, cheaper: improving shotgun proteomics by using high-speed ion trap mass spectrometry

ARC LIEF 2011

“Small talk: Communication networks between microbes.”

ARC Super Science 2011

“Beyond Proteomics: structure and function of protein modifications.”

ARC LIEF 2010

“A feasibility study on the development of a method for detection and analysis of exogenous growth hormone and its analogues using proteomics technology”

Dept. Health & Ageing (Anti-doping research program) 2008

“Proteomic biomarkers for translational colorectal cancer research”

NHMRC Career Development Award 2007

“Structural elucidation by chemical degradation mass spectrometry using a linear ion trap with electron transfer dissociation”

ARC LEIF 2007

“Differential Isotope Proteome Mapping of Transforming Growth Factor beta cell signaling”

ARC Discovery 2006

“Natural Product-derived Proteomics Probes for Specific Detection of Protein Kinase C Activities”

ARC Discovery 2006

 

Other Grants

Molecular analysis to refine risk of dissemination in early stage colorectal tumours and transformation potential of colorectal polyps

Colorectal Surgical Society ANZ Foundation 2018

Investigating the regulatory roles of Cyclin F phosphorylation in the development and prevention of Amyotrophic Lateral Sclerosis (ALS).

Motor Neuron Disease Research Institute Australia 2017

High content oncoproteomics for improved prognostication and treatment response.

Cancer Institute NSW 2017

Platform for cancer drug monitoring and metabolite analysis supporting clinical and scientific cancer research.

Cancer Institute NSW 2015

New approaches to plasma biomarker studies in MND/ALS.

Motor Neuron Disease Research Institute Australia 2015

(Translational Cancer Research Program) Northern Translational Cancer Research Centre.

Cancer Institute NSW 2014

Novel regulation of beta-catenin intracellular transport and its role in cell polarity and migration

NSW Cancer Council 2012

Regulation of APC intracellular dynamics and function.

NSW Cancer Council 2011

Higher sensitivity and deeper proteome analysis with the newest generation Orbitrap mass spectrometer.

Cancer Institute NSW 2011

A mass spectrometer for cancer biomarker research

Cancer Institute NSW 2010

Multiplexed quantitation of phosphoproteins in tumours as prognostic markers.

Cancer Institute NSW (Innovation Grant) 2010

Research Program in Cancer Proteomics

OSMR China-NSW Collaborative 2009

Lynchpin protein interactions that drive epithelial cancer malignancy

NSW Cancer Council 2008

Use of proteomic analyses to improve the management of colorectal cancer

Cancer Institute NSW Translational Program Grant 2007

A Mass Spectrometer for NSW Cancer Phosphoproteomics Research

Cancer Institute NSW (Infrastructure Grant) 2009

NSW Cancer Proteomics Research.

Cancer Institute NSW (Infrastructure Grant) 2005

Year Award/ Honour Institution
2016 Invited speaker 8th AsiaOceania Human Proteome Organisation meeting, SunMoon Lake,Taiwan.
2016 Invited speaker 15th Human Proteome Organisation meeting, Taipei, Taiwan
2016 Plenary Speaker German Mass Spectrometry Society annual meeting, Hamburg
2016 Invited Speaker Sydney Cancer Conference
2015 Invited Speaker Australian Peptide Conference – Omics satellite meeting
2015 Invited speaker Australian & New Zealand Society for Mass Spectrometry, Brisbane
2015 Keynote Speaker Korean Human Proteome Organisation annual meeting, Seoul
2015 Invited Speaker Australian Institute Bioengineering and Nanotechnology seminar
2014 Invited Speaker, “Where art thou biomarkers” Sydney Cancer Conference
2014 Invited Speaker ComBio2014, Canberra
2014 ABSciex user meeting American Society for Mass Spectrometry, Baltimore
2012 Pllenary Speaker “Discovery and targeted mass spectrometry for colorectal cancer research”  1st Malaysian Proteomics Conference, Penang
2011 ABSciex user meeting American Society for Mass Spectrometry, Utah.
2010 Invited Speaker “Predictive Plasma Biomarkers For Colorectal Cancer Chemotherapy” Australasian Proteomic Society Lorne Meeting
2010  “Predictive Plasma Biomarkers For Colorectal Cancer Chemotherapy” 9th Annual HUPO Meeting, Sydney
2009 “Predictive Plasma Biomarkers For Colorectal Cancer Chemotherapy” 8th Annual HUPO Meeting, Toronto
2008 ABSciex user meeting American Society for Mass Spectrometry, Denver
2008 Invited Speaker “Prognostic Biomarker Discovery In Colorectal Cancer Using Proteomics” 3rd HMRI Cancer Conference, Newcastle
2008 Invited Speaker “Protein Biomarkers Of Colorectal Cancer For Patient Prognosis And Improved Personalisation Of Chemotherapy” Australasian Proteomic Society Lorne Meeting
2007 Invited Speaker “Mass spectrometry based discovery and verification of clinical prognostic biomarkers for colorectal cancer” ComBio2007, Sydney
2007 “Unique SRM mass spectrometry to unequivocally identify and quantify all the proteins in a proteome” 6th Annual HUPO Meeting, Seoul, Korea
2007 “Multiple Reaction Monitoring for cancer research” 55th American Society for Mass Spectrometry (Applied Biosystems User Meeting)
2006 Invited Speaker “Stable Isotope Labelling for Quantitative Proteomics” Australasian Proteomic Society Lorne meeting
2006 “Development of protein and peptidomic biomarkers for colorectal cancer” 5th Annual HUPO Meeting, Long Beach, CA
2005 “Stable Isotope Labelling for Quantitative Proteomics” Proteomic Society NZ annual meeting, Dunedin, New Zealand
2005 Plenary presentation “Drilling Deeper into the Proteome” Annual Meeting of the American Electrophoresis Society/American Institute of Chemical Engineers, Cincinatti, OH
2004 Invited Speaker “Applications and Challenges for Proteomics in Drug Discovery” AHMRC, Sydney
2003 “Quantitative Proteomics: Applications in Drug Discovery” 2nd Annual HUPO Meeting, Montreal, Canada
2003 “Proteomics: Applications and challenges in drug discovery” Analytical Chemistry Gordon Research Conference, New London, CT
2002 Session Chair Annual Meeting of the American Electrophoresis Society/American Institute of Chemical Engineers – Indianapolis
2001 Meeting Organiser, workshop entitled “Proteomics: A review of current practices and future directions” Annual Meeting of the Society for Industrial Microbiology, St. Louis
2000 “Developments with alkaline isoelectric focusing for proteomics”  Eastern Analytical Symposium, Atlantic City
2000 “Proteomics of bacterial membranes” 4th Siena Meeting From Genome to Proteome
1998 Session Chair “Sequential extraction of bacterial outer membrane proteins by differential protein solubility” 3th Siena Meeting “From Genome to Proteome”

Mirzaei, M., Pascovici, D., Wu, J., Chick, J., Wu, Y., Cooke, B., Haynes, P., Molloy, M. (2017). TMT one-stop shop: From reliable sample preparation to computational analysis platform. In Shivakumar Keerthikumar and Suresh Mathivanan (Eds.), Proteome Bioinformatics, (pp. 45-66). New York: Springer. [More Information]

Fung, D., Lo, A., Jankova, L., Clarke, S., Molloy, M., Robertson, G., Wilkins, M. (2011). Classification of Cancer Patients Using Pathway Analysis and Network Clustering. In Gerard Cagney, Andrew Emili (Eds.), Network Biology: Methods and Applications, (pp. 311-336). New York: Humana Press.

Lin, C., Krisp, C., Packer, N., Molloy, M. (2018). Development of a data independent acquisition mass spectrometry workflow to enable glycopeptide analysis without predefined glycan compositional knowledge. Journal of Proteomics, 172, 68-75. [More Information]

Steffen, P., Krisp, C., Yi, W., Yang, P., Molloy, M., Schluter, H. (2018). Multi-laboratory analysis of the variability of shipped samples for proteomics following non-cooled international transport. Analytical Biochemistry, 548, 60-65. [More Information]

Lee, A., Rayner, S., Gwee, S., De Luca, A., Shahheydari, H., Sundaramoorthy, V., Ragagnin, A., Morsch, M., Radford, R., Galper, J., et al (2018). Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy. Cellular and Molecular Life Sciences, 75(2), 335-354. [More Information]

Bucio-Noble, D., Kautto, L., Krisp, C., Ball, M., Molloy, M. (2018). Polyphenol extracts from dried sugarcane inhibit inflammatory mediators in an in vitro colon cancer model. Journal of Proteomics, 177, 1-10. [More Information]

Bhatnagar, A., McKay, M., Crumbaker, M., Ahire, K., Karuso, P., Gurney, H., Molloy, M. (2018). Quantitation of the anticancer drug abiraterone and its metabolite (Delta)(4)-abiraterone in human plasma using high-resolution mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 154, 66-74. [More Information]

Mirzaei, M., Gupta, V., Chick, J., Greco, T., Wu, Y., Chitranshi, N., Vander Wall, R., Hone, E., Deng, L., Dheer, Y., You, Y., Graham, S., et al (2017). Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes. Scientific Reports, 7(1), 1-16. [More Information]

Lee, A., Rayner, S., De Luca, A., Gwee, S., Morsch, M., Sundaramoorthy, V., Shahheydari, H., Ragagnin, A., Shi, B., Yang, S., et al (2017). Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex. Open Biology, 7(10), 1-11. [More Information]

Hogan, A., Don, E., Rayner, S., Lee, A., Laird, A., Watchon, M., Winnick, C., Tarr, I., Morsch, M., Fifita, J., Nicholson, G., et al (2017). Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype. Human Molecular Genetics, 26(14), 2616-2626. [More Information]

Simonian, M., Ogorzalek Loo, R., Rannulu, N., Loo, J., Molloy, M., Stoodley, M. (2017). Identification of protein targets in cerebral endothelial cells for brain arteriovenous malformation (AVMs) molecular therapies. Clinical Proteomics, 14(1), 1-12. [More Information]

Wu, J., Pascovici, D., Ignjatovic, V., Song, X., Krisp, C., Molloy, M. (2017). Improving Protein Detection Confidence Using SWATH-Mass Spectrometry with Large Peptide Reference Libraries. Proteomics, 17(19). [More Information]

McRobb, L., McKay, M., Gamble, J., Grace, M., Moutrie, V., Santos, E., Lee, V., Zhao, Z., Molloy, M., Stoodley, M. (2017). Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence. Aging, 9(4), 1248-1268. [More Information]

Collins, B., Hunter, C., Liu, Y., Schilling, B., Rosenberger, G., Bader, S., Chan, D., Gibson, B., Gingras, A., Held, J., et al (2017). Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry. Nature Communications, 8(1), 1-12. [More Information]

Agbaje, O., Thomas, D., Mclnerney, B., Molloy, M., Jacob, D. (2017). Organic macromolecules in shells of Arctica islandica: comparison with nacroprismatic bivalve shells. Marine Biology, 164(11), 1-13. [More Information]

Tan, S., Lee, A., Pascovici, D., Care, N., Birzniece, V., Ho, K., Molloy, M., Khan, A. (2017). Plasma biomarker proteins for detection of human growth hormone administration in athletes. Scientific Reports, 7(1). [More Information]

Kamath, K., Krisp, C., Chick, J., Pascovici, D., Gygi, S., Molloy, M. (2017). Pseudomonas aeruginosa Proteome under Hypoxic Stress Conditions Mimicking the Cystic Fibrosis Lung. Journal of Proteome Research, 16(10), 3917-3928. [More Information]

Bjelosevic, S., Pascovici, D., Ping, H., Karlaftis, V., Zaw, T., Song, X., Molloy, M., Monagle, P., Ignjatovic, V. (2017). Quantitative age-specific variability of plasma proteins in healthy neonates, children and adults. Molecular and Cellular Proteomics, 16(5), 924-935. [More Information]

McRobb, L., Lee, V., Simonian, M., Zhao, Z., Thomas, S., Wiedmann, M., Amal Raj, J., Grace, M., Moutrie, V., McKay, M., et al (2017). Radiosurgery Alters the Endothelial Surface Proteome: Externalized Intracellular Molecules as Potential Vascular Targets in Irradiated Brain Arteriovenous Malformations. Radiation Research, 187(1), 66-78. [More Information]

Krisp, C., Molloy, M. (2017). SWATH mass spectrometry for proteomics of non-depleted plasma. Methods in Molecular Biology, 1619, 373-383. [More Information]

Johnson, A., Zaman, M., Veljanoski, F., Phrakaysone, A., Li, S., O’Doherty, P., Petersingham, G., Perrone, G., Molloy, M., Wu, M. (2017). Unravelling the role of protein kinase CK2 in metal toxicity using gene deletion mutants. Metallomics, 9(3), 301-308. [More Information]

Kao, S., Kirschner, M., Cooper, W., Tran, T., Burgers, S., Wright, C., Korse, T., van den Broek, D., Edelman, J., Vallely, M., McCaughan, B., Pavlakis, N., Clarke, S., van Zandwijk, N., Reid, G., et al (2016). A proteomics-based approach identifies secreted protein acidic and rich in cysteine as a prognostic biomarker in malignant pleural mesothelioma. British Journal of Cancer, 114(5), 524-531. [More Information]

Song, X., Amirkhani, A., Wu, J., Pascovici, D., Zaw, T., Xavier, D., Clarke, S., Molloy, M. (2016). Analytical performance of nano-LC-SRM using nondepleted human plasma over an 18-month period. Proteomics, 16(15-16), 2118-2127. [More Information]

Williams, K., Topp, S., Yang, S., Smith, B., Fifita, J., Warraich, S., Zhang, K., Farrawell, N., Vance, C., Dobson-Stone, C., Cole, N., Nicholson, G., et al (2016). CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia. Nature Communications, 7, 1-8. [More Information]

Al-Eisawi, Z., Beale, P., Chan, C., Yu, J., Proschogo, N., Molloy, M., Huq, F. (2016). Changes in the in vitro activity of platinum drugs when administered in two aliquots. BMC Cancer, 16(1), 1-25. [More Information]

Morris, K., O’Meally, D., Zaw, T., Song, X., Gillett, A., Molloy, M., Polkinghorne, A., Belov, K. (2016). Characterisation of the immune compounds in koala milk using a combined transcriptomic and proteomic approach. Scientific Reports, 6, 1-14. [More Information]

Jamieson, C., Mills, K., Lui, C., Semaan, C., Molloy, M., Sharma, M., Forwood, J., Henderson, B. (2016). Characterization of a beta-catenin nuclear localization defect in MCF-7 breast cancer cells. Experimental Cell Research, 341(2), 196-206. [More Information]

Hayes, S., Haefliger, S., Harris, B., Pavlakis, N., Clarke, S., Molloy, M., Howell, V. (2016). Exhaled breath condensate for lung cancer protein analysis: a review of methods and biomarkers. Journal of Breath Research, 10(3), 1-26. [More Information]

Succar, P., Medynskyj, M., Breen, E., Batterham, T., Molloy, M., Herbert, B. (2016). Priming Adipose-Derived Mesenchymal Stem Cells with Hyaluronan Alters Growth Kinetics and Increases Attachment to Articular Cartilage. Stem Cells International, 2016, 1-13. [More Information]

Martinez-Aguilar, J., Clifton-Bligh, R., Molloy, M. (2016). Proteomics of thyroid tumours provides new insights into their molecular composition and changes associated with malignancy. Scientific Reports, 6, 1-12. [More Information]

Kamath, K., Pascovici, D., Penesyan, A., Goel, A., Venkatakrishnan, V., Paulsen, I., Packer, N., Molloy, M. (2016). Pseudomonas aeruginosa Cell Membrane Protein Expression from Phenotypically Diverse Cystic Fibrosis Isolates Demonstrates Host-Specific Adaptations. Journal of Proteome Research, 15(7), 2152-2163. [More Information]

Wu, J., Song, X., Pascovici, D., Zaw, T., Care, N., Krisp, C., Molloy, M. (2016). SWATH mass spectrometry performance using extended peptide MS/MS assay libraries. Molecular and Cellular Proteomics, 15(7), 2501-2514. [More Information]

Martinez-Aguilar, J., Clifton-Bligh, R., Molloy, M. (2015). A multiplexed, targeted mass spectrometry assay of the S100 protein family uncovers the isoform-specific expression in thyroid tumours. BMC Cancer, 15(1), 1-14. [More Information]

Pascovici, D., Song, X., Solomon, P., Winterberg, B., Mirzaei, M., Goodchild, A., Stanley, W., Liu, J., Molloy, M. (2015). Combining Protein Ratio p-Values as a Pragmatic Approach to the Analysis of Multirun iTRAQ Experiments. Journal of Proteome Research, 14(2), 738-746. [More Information]

Mahon, K., Lin, H., Castillo, L., Lee, B., Lee-Ng, K., Chatfield, M., Chiam, K., Breit, S., Brown, D., Molloy, M., Marx, G., Pavlakis, N., Boyer, M., Stockler, M., Horvath, L., et al (2015). Cytokine profiling of docetaxel-resistant castration-resistant prostate cancer. British Journal of Cancer, 112(8), 1340-1348. [More Information]

Meex, R., Hoy, A., Morris, A., Brown, R., Lo, J., Burke, M., Goode, R., Kingwell, B., Kraakman, M., Febbraio, M., et al (2015). Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism. Cell Metabolism, 22(6), 1078-1089. [More Information]

Penesyan, A., Kumar, S., Kamath, K., Shathili, A., Venkatakrishnan, V., Krisp, C., Packer, N., Molloy, M., Paulsen, I. (2015). Genetically and phenotypically distinct pseudomonas aeruginosa cystic fibrosis isolates share a core proteomic signature. PloS One, 10(10), 1-26. [More Information]

Percy, A., Tamura-Wells, J., Albar, J., Aloria, K., Amirkhani, A., Araujo, G., Arizmendi, J., Blanco, F., Canals, F., Cho, J., et al (2015). Inter-laboratory evaluation of instrument platforms and experimental workflows for quantitative accuracy and reproducibility assessment. EuPA Open Proteomics, 8, 6-15. [More Information]

Lin, C., Chik, J., Packer, N., Molloy, M. (2015). Multidimensional fractionation is a requirement for quantitation of golgi-resident glycosylation enzymes from cultured human cells. Journal of Proteome Research, 14(2), 747-755. [More Information]

Krisp, C., Yang, H., van Soest, R., Molloy, M. (2015). Online peptide fractionation using a multiphasic microfluidic liquid chromatography chip improves reproducibility and detection limits for quantitation in discovery and targeted proteomics. Molecular and Cellular Proteomics, 14(6), 1708-1719. [More Information]

Parker, R., Vella, L., Xavier, D., Amirkhani, A., Parker, J., Cebon, J., Molloy, M. (2015). Phosphoproteomic analysis of cell-based resistance to BRAF inhibitor therapy in melanoma. Frontiers in Oncology, 5(MAY), 1-13. [More Information]

Kamath, K., Kumar, S., Kaur, J., Venkatakrishnan, V., Paulsen, I., Nevalainen, H., Molloy, M. (2015). Proteomics of hosts and pathogens in cystic fibrosis. Proteomics – Clinical Applications, 9, 134-146. [More Information]

Jankova, L., Dent, O., Molloy, M., Chan, C., Chapuis, P., Howell, V., Clarke, S. (2015). Reporting in studies of protein biomarkers of prognosis in colorectal cancer in relation to the REMARK guidelines. Proteomics – Clinical Applications, 9(11-12), 1078-1086. [More Information]

Schilter, H., Cantemir-Stone, C., Leksa, V., Ohradanova-Repic, A., Findlay, A., Deodhar, M., Stockinger, H., Song, X., Molloy, M., Marsh, C., et al (2015). The mannose-6-phosphate analogue, PXS64, inhibits fibrosis via TGF-?1 pathway in human lung fibroblasts. Immunology Letters, 165(2), 90-101. [More Information]

Chik, J., Zhou, J., Moh, E., Christopherson, R., Clarke, S., Molloy, M., Packer, N. (2014). Comprehensive glycomics comparison between colon cancer cell cultures and tumours: Implications for biomarker studies. Journal of Proteomics, 108, 146-162. [More Information]

Hayes, S., Hudson, A., Clarke, S., Molloy, M., Howell, V. (2014). From mice to men: GEMMs as trial patients for new NSCLC therapies. Seminars in Cell & Developmental Biology, 27, 118-127. [More Information]

Parker, R., Clifton-Bligh, R., Molloy, M. (2014). Phosphoproteomics of MAPK inhibition in BRAF mutated cells and a role for the lethal synergism of dual BRAF and CK2 inhibition. Molecular Cancer Therapeutics, 13(7), 1894-1906. [More Information]

Voros, A., Simm, R., Slamti, L., McKay, M., Hegna, I., Nielsen-LeRoux, C., Hassan, K., Paulsen, I., Molloy, M., et al (2014). SecDF as part of the sec-translocase facilitates efficient secretion of Bacillus cereus toxins and cell wall-associated proteins. PloS One, 9(8). [More Information]

Hart-Smith, G., Chia, S., Low, J., McKay, M., Molloy, M., Wilkins, M. (2014). Stoichiometry of Saccharomyces cerevisiae Lysine Methylation: Insights into Non-histone Protein Lysine Methyltransferase Activity. Journal of Proteome Research, 13(3), 1744-1756. [More Information]

Winterberg, B., Du Fall, L., Song, X., Pascovici, D., Care, N., Molloy, M., Ohms, S., Solomon, P. (2014). The necrotrophic effector protein SnTox3 re-programs metabolism and elicits a strong defence response in susceptible wheat leaves. BMC Plant Biology, 14(1), 1-15. [More Information]

Pascovici, D., Gardiner, D., Song, X., Breen, E., Solomon, P., Keighley, T., Molloy, M. (2013). Coverage and consistency: Bioinformatics aspects of the analysis of multirun iTRAQ experiments with wheat leaves. Journal of Proteome Research, 12(11), 4870-4881. [More Information]

Martinez-Aguilar, J., Molloy, M. (2013). Label-free selected reaction monitoring enables multiplexed quantitation of S100 protein isoforms in cancer cells. Journal of Proteome Research, 12(8), 3679-3688. [More Information]

Krisp, C., Jacobsen, F., McKay, M., Molloy, M., Steinstraesser, L., Wolters, D. (2013). Proteome analysis reveals antiangiogenic environments in chronic wounds of diabetes mellitus type 2 patients. Proteomics, 13(17), 2670-2681. [More Information]

Martinez-Aguilar, J., Chik, J., Nicholson, J., Semaan, C., McKay, M., Molloy, M. (2013). Quantitative mass spectrometry for colorectal cancer proteomics. Proteomics – Clinical Applications, 7(1-Feb), 42-54. [More Information]

Lee, A., Molloy, M., Baker, M., Kapur, A. (2013). Tandem ion exchange fractionation of chicken egg white reveals the presence of proliferative bioactivity. Journal of Agricultural and Food Chemistry, 61(17), 4079-4088. [More Information]

Molloy, M. (2013). Two-stepping to increase peptide spectra matches in large databases. Proteomics, 13(8), 1229-30. [More Information]

Nicholson, J., Neelagandan, K., Huart, A., Ball, K., Molloy, M., Hupp, T. (2012). An iTRAQ Proteomics Screen Reveals the Effects of the MDM2 Binding Ligand Nutlin-3 on Cellular Proteostasis. Journal of Proteome Research, 11(11), 5464-5478. [More Information]

Jankova, L., Robertson, G., Chan, C., Tan, K., Kohonen-Corish, M., Fung, C., Clarke, C., Lin, B., Molloy, M., Chapuis, P., Bokey, E., Dent, O., Clarke, S. (2012). Glutathione S-transferase Pi expression predicts response to adjuvant chemotherapy for stage C colon cancer: a matched historical control study. BMC Cancer, 12, 1-9. [More Information]

Krisp, C., McKay, M., Wolters, D., Molloy, M. (2012). Multidimensional protein identification technology-selected reaction monitoring improving detection and quantification for protein biomarker studies. Analytical Chemistry, 84(3), 1592-1600. [More Information]

Sigglekow, N., Pangon, L., Brummer, T., Molloy, M., Hawkins, N., Ward, R., Musgrove, E., Kohonen-Corish, M. (2012). Mutated in colorectal cancer protein modulates the NF?B pathway. Anticancer Research, 32(1), 73-79.

Kho, P., Jankova, L., Fung, C., Chan, C., Clarke, C., Lin, B., Robertson, G., Molloy, M., Chapuis, P., Bokey, E., Dent, O., Clarke, S. (2012). Overexpression of protein S100A4 is independently associated with overall survival in stage C colonic cancer but only in cytoplasm at the advancing tumour front. International Journal of Colorectal Disease, 27(11), 1409-1417. [More Information]

Randall, S., McKay, M., Pascovici, D., Mahon, K., Horvath, L., Clarke, S., Molloy, M. (2012). Remarkable temporal stability of high-abundance human plasma proteins assessed by targeted mass spectrometry. Proteomics – Clinical Applications, 6(11-12), 626-634. [More Information]

Sharma, M., Jamieson, C., Johnson, M., Molloy, M., Henderson, B. (2012). Specific Armadillo Repeat Sequences Facilitate beta-Catenin Nuclear Transport in Live Cells via Direct Binding to Nucleoporins Nup62, Nup153, and RanBP2/Nup358. Journal of Biological Chemistry, 287(2), 819-831. [More Information]

Krisp, C., Randall, S., McKay, M., Molloy, M. (2012). Towards clinical applications of selected reaction monitoring for plasma protein biomarker studies. Proteomics – Clinical Applications, 6(1-2), 42-59. [More Information]

Sherman, J., Molloy, M., Burlingame, A. (2012). Why complexity and entropy matter: Information, posttranslational modifications, and assay fidelity. Proteomics, 12(8), 1147-1150. [More Information]

Tan, K., Jankova, L., Chan, C., Fung, C., Clarke, C., Lin, B., Robertson, G., Molloy, M., Chapuis, P., Bokey, E., Clarke, S., et al (2011). Clinicopathological correlates and prognostic significance of glutathione S-transferase Pi expression in 468 patients after potentially curative resection of node-positive colonic cancer. Histopathology, 59(6), 1057-1070. [More Information]

Yang, J., MacDougall, M., McDowell, M., Xi, L., Wei, R., Zavadoski, W., Molloy, M., Baker, J., Kuhn, M., Cabrera, O., et al (2011). Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes. BMC Genomics, 12, 1-14. [More Information]

Jankova, L., Chan, C., Fung, C., Song, X., Kwun, S., Cowley, M., Kaplan, W., Dent, O., Bokey, E., Chapuis, P., Robertson, G., Clarke, S., et al (2011). Proteomic comparison of colorectal tumours and non-neoplastic mucosa from paired patient samples using iTRAQ mass spectrometry. Molecular BioSystems, 7(11), 2997-3005. [More Information]

Dolai, S., Xu, Q., Liu, F., Molloy, M. (2011). Quantitative chemical proteomics in small-scale culture of phorbol ester stimulated basal breast cancer cells. Proteomics, 11(13), 2683-2692. [More Information]

Ali, N., Molloy, M. (2011). Quantitative phosphoproteomics of transforming growth factor-β signaling in colon cancer cells. Proteomics, 11(16), 3390-401. [More Information]

Fung, C., Chan, C., Jankova, L., Dent, O., Robertson, G., Molloy, M., Bokey, E., Chapuis, P., Lin, B., Clarke, S. (2010). Clinicopathological correlates and prognostic significance of maspin expression in 450 patients after potentially curative resection of node-positive colonic cancer. Histopathology, 56(3), 319-330. [More Information]

Lam, F., Jankova, L., Dent, O., Molloy, M., Kwun, S., Clarke, C., Chapuis, P., Robertson, G., Beale, P., Clarke, S., Bokey, E., Chan, C. (2010). Identification of distinctive protein expression patterns in colorectal adenoma. Proteomics – Clinical Applications, 4(1), 60-70. [More Information]

Zhao, L., Lee, B., Brown, D., Molloy, M., Marx, G., Pavlakis, N., Boyer, M., Stockler, M., Kaplan, W., Breit, S., et al (2009). Identification of candidate biomarkers of therapeutic response to docetaxel by proteomic profiling. Cancer Research, 69(19), 7696-7703. [More Information]

McKay, M., Sherman, J., Laver, M., Baker, M., Clarke, S., Molloy, M. (2007). The development of multiple reaction monitoring assays for liver-derived plasma proteins. Proteomics – Clinical Applications, 1(12), 1570-1581. [More Information]

For more information please contact:

Phone: +61 2 99267870

Email: m.molloy@sydney.edu.au